# Core D: Neuropathology Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $422,774

## Abstract

ABSTRACT – NEUROPATHOLOGY CORE
The overall goal of the Neuropathology Core of the Rush ADCC is to facilitate innovative translational clinical-
pathologic, molecular, and biochemical research that can overcome critical barriers in scientific progress on the
pathogenesis of cognitive decline and transitions from normal aging to mild cognitive impairment and
dementia, ultimately leading to better preventions, accurate and meaningful biomarkers, and effective
interventions. The Core will do this by collecting and then providing a diverse range of investigators a resource
of optimally preserved, processed and stored biospecimens, and state-of-the-art neuropathologic data and
diagnoses, from clinically well-characterized older subjects. Over the past funding cycle, the Core has
continued to support a diverse range of studies including those that link pathology to normal aging and
transitions to dementia, link risk factors to pathology, and link data from contemporary biochemical and
molecular techniques to risk factors, cognitive decline, and transitions. In addition, the core has distributed
biospecimens to externally-funded investigators at Rush, at other NIA funded Alzheimer’s disease centers, and
to researchers across the country and internationally. The Neuropathology Core has facilitated the publication
of numerous manuscripts in peer-reviewed journals. In the new funding cycle, the Core will continue to
facilitate these studies and publications by continuing to practice optimal autopsy and collection procedures to
obtain ante-mortem and post-mortem specimens and continue to use the uniform, standard and flexible
techniques for preservation, processing and storage that allows for diverse research studies. The core will
maintain a DNA bank for all living and deceased participants. The Core will continue to use state-of-the-art
diagnostic assessments on brain tissue to diagnose and quantify Alzheimer’s disease, cerebral infarct, Lewy
body disease, hippocampal sclerosis, and TDP-43 pathology and will expand assessments to include the
olfactory bulbs and watershed regions. Using modern data management systems the Neuropathology Core
will index and store data and diagnoses making these readily available for external research. The
Neuropathology Core will continue to distribute high quality specimens and neuropathologic data and
diagnoses to support externally funded investigators to facilitate and expand the scope of research on normal
aging and transitions to dementia.

## Key facts

- **NIH application ID:** 9977091
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Julie A. Schneider
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $422,774
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977091

## Citation

> US National Institutes of Health, RePORTER application 9977091, Core D: Neuropathology Core (5P30AG010161-30). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977091. Licensed CC0.

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