# Core G: Religious Orders Study Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $757,506

## Abstract

ABSTRACT – RELIGIOUS ORDERS STUDY CORE
The overall goal of the Religious Orders Study Core is to continue to facilitate externally funded high quality
research on MCI, AD, and related disorders. The Core supports a variety of studies by investigators at Rush
and across the county, including studies of the transition from normality to MCI to AD; studies linking post-
mortem findings to the spectrum of cognition from normality, to MCI, to AD; and studies that link genetic and
environmental risk factors to post-mortem indices and clinical data obtained proximate to death; studies that
support drug discovery pipelines with contemporary high throughput biochemical and molecular techniques;
and studies of the causes, consequences, and neurobiology of impaired motor function.
The Core will continue recruiting and performing annual evaluations on older members of Catholic Religious
Communities without dementia. More than 1,300 participants have enrolled. The overall follow-up rate exceeds
95% with up to 22 waves of data, and the autopsy rate exceeds 90% with more than 650 autopsies.
More than 350 peer-reviewed manuscripts have been published including 201 in the past project period. The
manuscripts have been published by a wide variety of authors from Rush, and many other NIA-funded AD
Centers, and other centers in the United States, Canada, and Europe, and have had a strong and sustained
impact on the field
The continuation of this Core for five more years will result in up to 27 waves of data on more than 1450
persons and brain tissue from about 800 persons. Such a rich and diverse resource will allow the Core to
continue to support numerous investigators. It will also offer the AD research community unprecedented
opportunities to mine multi-level omics data to find novel therapeutic targets for all common neurodegenerative
diseases of aging.

## Key facts

- **NIH application ID:** 9977094
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** DAVID ALAN BENNETT
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $757,506
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977094

## Citation

> US National Institutes of Health, RePORTER application 9977094, Core G: Religious Orders Study Core (5P30AG010161-30). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9977094. Licensed CC0.

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