# Core H: Latino Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $504,160

## Abstract

ABSTRACT - LATINO CORE
The Rush Alzheimer's Disease Core Center (Rush ADCC; P30AG10161) supports the performance of
innovative research on the etiology, pathogenesis, diagnosis, treatment, and prevention of AD and related
conditions, by providing researchers with a stimulating inter-disciplinary environment, and unique and highly
valued clinical and post-mortem data, and biologic specimens. The Rush ADCC has eight cores that support a
variety of timely and important areas of research including risk factors for the transition from normal aging to
MCI to AD, the neurobiology of normal aging and MCI, and the use of contemporary omics technologies to
identify novel therapeutic targets.
The Rush ADCC has enrolled large numbers of Blacks and Whites without dementia into the Clinical and
Religious Orders Study Cores. Although the Latino community has not been a major focus, considerable
progress in the Latino community to date has set the stage for the Latino Core. The overall goal of the Latino
Core, funded in August, 2015, is to enroll and follow older Latinos free of dementia at baseline, and
generate data and ante- and post-mortem biospecimens, to support high quality, cutting edge,
externally-funded studies that focus on the full spectrum of cognition. These goals will be addressed with
four Specific Aims designed to enhance the Rush ADCC and the wider ADC research community:
Aim 1 is to recruit and enroll older Latinos without dementia who agree to annual, detailed clinical evaluations
and the collection of ante-mortem biologic specimens. Aim 2 is to conduct uniform structured baseline and
annual follow-up evaluations, including neurological examinations and neuropsychological and motor
performance testing, of community-dwelling Latinos, and apply uniform diagnostic criteria for incident AD and
MCI, and harmonize data collection with the Religious Orders Study Core and the Clinical Core to facilitate
health disparities research. Aim 3 is to integrate innovative and culturally tailored educational programs into
the clinical evaluation to increase awareness of the importance of brain and spinal cord autopsy in Latinos and
to facilitate a high autopsy rate with a short post-mortem interval; and harvest and preserve brain tissue in a
fashion that retains maximum flexibility to support a diverse array of studies. Aim 4 is to increase the capacity
to conduct externally-funded research, including studies that incorporate contemporary biochemical and
molecular techniques and clinical trials, by providing an environment and resources to facilitate the inclusion of
subjects, clinical data, and post-mortem tissue into research projects and to provide training opportunities for
junior faculty.

## Key facts

- **NIH application ID:** 9977095
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** DAVID X MARQUEZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $504,160
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977095

## Citation

> US National Institutes of Health, RePORTER application 9977095, Core H: Latino Core (5P30AG010161-30). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977095. Licensed CC0.

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