# Neuroimaging Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $502,442

## Abstract

ABSTRACT
The overall goal of the proposed revision is to develop a Neuroimaging Core in the Rush Alzheimer’s Disease
Core Center (Rush ADCC) that will build a resource of neuroimaging data from the Rush ADCC African
Americans and Latinos and from ancillary studies, and will provide neuroimaging expertise to facilitate high
quality, cutting edge, externally funded research focusing on the transition from normal aging to mild cognitive
impairment (MCI) to the earliest stages of Alzheimer’s disease (AD) and other dementias. Specifically, the
Neuroimaging Core will collect high quality, multi-modal, longitudinal in-vivo brain magnetic resonance imaging
(MRI) data from African American and Latino participants of the Clinical and Latino Cores who agree to
autopsy, and will integrate the new data along with a large volume of in-vivo and ex-vivo MRI data from
separately funded studies, all based on state-of-the-art, uniform data acquisition protocols. The Neuroimaging
Core will perform thorough quality checks and detailed processing of the in-vivo and ex-vivo MRI data in the
database to generate rich output on the macro-structural, micro-structural, chemical, and functional
characteristics of the older adult brain. The proposed Neuroimaging Core will build upon strengths of the Rush
ADCC including A) longitudinal clinical assessment of persons who enroll without dementia, B) longitudinal
ante-mortem biofluid collection, and C) post-mortem biospecimen collection from large numbers of persons,
many without dementia. The Neuroimaging Core of the Rush ADCC will widely distribute all brain MRI data
and processing results to investigators within and outside of the Rush ADCC, and will provide neuroimaging
expertise in support of research efforts in normal aging, cognitive decline, mild cognitive impairment, AD and
related dementias. The contributions of the Neuroimaging Core will stimulate research that A) develops novel
imaging biomarkers of age-related neuropathologies and molecular genetics generated from human brain and
blood from the same persons, B) elucidates brain mechanisms supporting cognitive and motor health or
leading to decline, C) evaluates the effects of risk factors on the brain, and D) ascertains the role of various
brain characteristics in racial/ethnic disparities of cognitive aging related outcomes.

## Key facts

- **NIH application ID:** 9977097
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Konstantinos Arfanakis
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $502,442
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977097

## Citation

> US National Institutes of Health, RePORTER application 9977097, Neuroimaging Core (5P30AG010161-30). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977097. Licensed CC0.

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