# Core B: Genetically Engineered Mouse Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $283,615

## Abstract

Project Summary/Abstract (Core B, Barton)
Core B of this Program Project Grant (P01) will maintain a colony of mouse strains with deficiencies in
components of innate immunity or other genetic modifications useful for the study of innate immunity and the
host response to pathogens. Core B also supports the generation of new mouse strains using Cas9-mediated
genome editing. This new technology enables rapid and affordable generation of knock-out and knock-in mice.
Core B will work with each of the Project Labs to develop new mouse strains that will facilitate hypothesis
testing. Mice are cells from the mice maintained within Core B will be distributed to each of the projects within
the P01. All mouse strains have been or will be backcrossed onto the C57BL/6J genetic background to
equivalent degrees. Core B will reduce overall mouse costs due to economies of scale. In addition, each P01
project will benefit from using cells and mice with fewer genetic and experimental variations.

## Key facts

- **NIH application ID:** 9977103
- **Project number:** 5P01AI063302-17
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Gregory M Barton
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $283,615
- **Award type:** 5
- **Project period:** 2004-12-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977103

## Citation

> US National Institutes of Health, RePORTER application 9977103, Core B: Genetically Engineered Mouse Core (5P01AI063302-17). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977103. Licensed CC0.

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