# APOLLO - Upper Midwest

> **NIH NIH U01** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $341,139

## Abstract

ABSTRACT
Recipients of a kidney transplant from an African-American deceased donor have worse
outcomes than their counterparts receiving an organ from a White deceased donor. The extent
to which this is due to the presence of high-risk APOL1 genotypes in African-American donors is
unknown. Several recent studies have found a positive association between high-risk APOL1
genotypes and graft failure, but these have been based on relatively few events, have come
primarily from a few large centers, and have not analyzed donor-recipient pairs. The proposed
studies will investigate the association of a kidney donor's APOL1 status with recipient
outcomes. We will also study estimate the impact of APLO1 status on living donor outcomes.
We have assembled a consortium including 6 organ procurement organizations covering 7
states in the Upper Midwest, 123 recovering hospitals, 25 transplant centers and collaborators
in transplant surgery, transplant nephrology, epidemiology and genetics to achieve these goals.
These findings will provide a greater understanding of the impact of the presence of high-risk
APOL1 variants in both recipients and living donors. These data are needed for informed
decision-making for recipients, potential living donors, and their caregivers. Both the relative and
absolute risk of clinically significant events associated with high-risk APOL1 variants will be
estimated with much greater precision that previous studies, allowing more informed decisions
on acceptance of specific organs for transplantation.

## Key facts

- **NIH application ID:** 9977188
- **Project number:** 5U01DK116092-04
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Brad C Astor
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $341,139
- **Award type:** 5
- **Project period:** 2017-09-25 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977188

## Citation

> US National Institutes of Health, RePORTER application 9977188, APOLLO - Upper Midwest (5U01DK116092-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9977188. Licensed CC0.

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