# TRD1: Quantitative Biomechanics Imaging

> **NIH NIH P41** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $340,916

## Abstract

Project Summary 
TRD 1 
The proposed research in TRD Project 1 is to develop novel optical coherence tomography (OCT)-based 
techniques and tools for measuring the mechanical properties and parameters as well as acoustic transduction 
in tissues. The focus on tissue biomechanics responds to the emerging opportunity to harness OCT's unique 
capabilities to obtain quantitative maps of tissue vibration, deformation, strain, and force at high precision and 
high spatiotemporal resolution. Specific aims are directly motivated by the challenges identified in Collaborative 
Projects. Aim 1 is to develop probe-based OCT vibrography for analysis of middle and inner ears. A cellular- 
resolution probe with a diameter of 1 mm will be developed, tested, and validated in vivo with genetically 
modified mouse models of hearing disorders. Furthermore, the ability to image the 3D structure and sound- 
driven vibration of the inner working of human cochlea in cadaveric specimens will be established. Aim 2 of the 
proposed research is to develop corneal elastography based on noncontact acoustic vibration. Finite-element 
methods to map corneal stiffness from vibrational images will be developed and tested in a pilot human study 
involving normal and LASIK-treated subjects. Aim 3 of TRD-1 is to develop micro-sized inclusion sensors for 
OCT elastography for mapping force, strain, and stiffness with greatly enhanced accuracy. This tool and 
computational algorithm will be tested for quantitative biomechanics mapping of the optic nerve head. Through 
these combined aims, TRD-1 strives to help the community advance fundamental knowledge and improve the 
diagnosis and treatments of diseases through technical innovations.

## Key facts

- **NIH application ID:** 9977194
- **Project number:** 5P41EB015903-10
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Seok-Hyun Andy Yun
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $340,916
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977194

## Citation

> US National Institutes of Health, RePORTER application 9977194, TRD1: Quantitative Biomechanics Imaging (5P41EB015903-10). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9977194. Licensed CC0.

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