# Cardiac Toxicity in Perinatally HIV-Infected Adolescents and Young Adults, a Longitudinal Study

> **NIH NIH R01** · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2020 · $672,429

## Abstract

Project Summary
 While the widespread use of highly active antiretroviral therapy has markedly decreased cardiac
morbidity and mortality in perinatally HIV-infected children, several studies have suggested subclinical
abnormalities in echocardiographic measures of left ventricular structure and function. The goal of this study is
to longitudinally evaluate the cardiovascular status of perinatally HIV-infected adolescents and young adults
and to explore whether chronic inflammation and/or mitochondrial abnormalities are associated with
echocardiographic and biomarker changes over time. The specific aims of this study are to 1) to determine
longitudinal changes of cardiovascular risk factors that were assessed ~6 years ago in the AMP (adolescents)
and AMP Up (young adults) perinatally HIV-infected (PHIV) and HIV-exposed, uninfected (PHEU) cohorts of
the Pediatric HIV/AIDS Cohort Study (PHACS); and to measure modified Pathobiological Determinants of
Atherosclerosis in Youth or PDAY scores (a measure of aggregate cardiovascular risk) in HIV-infected
adolescents longitudinally; and 2) To determine the role of systemic mitochondrial dysfunction in
cardiovascular abnormalities and biomarkers by assaying mitochondrial DNA (mtDNA) copies/cell, oxidative
phosphorylation (OXPHOS) enzyme activities, oxygen consumption (respiration), and mitochondrial oxidative
stress. The results of this study can identify if there are perinatally HIV-infected adolescents and young adults,
with long term exposure to HAART, which are at increased risk of future cardiovascular morbidities. If this is
the case, the results of this study can inform various interventions in this increased cardiovascular risk group to
decrease their future risk of adverse cardiovascular events.

## Key facts

- **NIH application ID:** 9977275
- **Project number:** 5R01HL137558-04
- **Recipient organization:** STATE UNIVERSITY OF NEW YORK AT BUFFALO
- **Principal Investigator:** STEVEN EDWARD LIPSHULTZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $672,429
- **Award type:** 5
- **Project period:** 2017-09-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977275

## Citation

> US National Institutes of Health, RePORTER application 9977275, Cardiac Toxicity in Perinatally HIV-Infected Adolescents and Young Adults, a Longitudinal Study (5R01HL137558-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9977275. Licensed CC0.

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