# A microRNA-target Network in Endothelial DNA Damage and Angiogenesis

> **NIH NIH R01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $382,270

## Abstract

Project Summary
Endothelial cells play an important role in regulating several aspects of cardiovascular health. Our lab has
identified a group of seven microRNAs (miRs) that are upregulated during DNA damage and oxidative stress in
endothelial cells. Some of these miRs induce DNA damage, cell death and senescence in endothelial cells in
vitro and in vivo. We have characterized a DNA damage network as being targets of these miRs. This proposal
aims to investigate A) How these miRs are regulated in response to stressors? B) What are the mechanisms
by which these miR-target network interactions lead to endothelial death and dysfunction and finally C)
evaluate a novel anti-angiogenic strategy by targeting this miR-target network and any potential synergy with
VEGF inhibition in vivo. Our studies will establish a new paradigm for inhibiting angiogenesis using miR-
mediated disruption of DNA repair.

## Key facts

- **NIH application ID:** 9977284
- **Project number:** 5R01HL137779-03
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Sudarshan Anand
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $382,270
- **Award type:** 5
- **Project period:** 2018-09-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977284

## Citation

> US National Institutes of Health, RePORTER application 9977284, A microRNA-target Network in Endothelial DNA Damage and Angiogenesis (5R01HL137779-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9977284. Licensed CC0.

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