# Microglial and macrophage potassium channels as regulators of neuroinflammation in Alzheimer's Disease

> **NIH NIH K08** · EMORY UNIVERSITY · 2020 · $188,652

## Abstract

Project summary/Abstract
Candidate
I am a board-certified neurologist committed to a career in health-oriented basic and translational research. I
have research expertise in ion channel biology and immunology, clinical research methods and clinical
neurology. My long-term goal is to establish myself as a successful independent physician-scientist in
neuroinflammation and translational neuroscience. To achieve this goal and facilitate my transition to
independence, I seek 5 years of mentored training through a NIH K08 career development award to fill gaps in
my research training, establish a network of future research collaborators, build my publication record and
grant-writing skills and pursue training in leadership and faculty development.
Environment
The training and mentoring environment at Emory is ideally suited for my career development. My mentorship
committee at Emory University is comprised of experts and independent scientists in the fields of
neurodegeneration (Dr. Allan Levey), neuroinflammation (Dr. Malu Tansey) and proteomics/systems biology
(Dr. Nicholas Seyfried), each with exemplary records of NIH and non-federal funding, leading successful and
productive research groups and training post-doctoral and physician-scientist trainees. My mentors and their
research groups will provide me with hands-on training in (1) Animal models of neurodegeneration as tools to
facilitate translational research, (2) Functional assays of microglia and macrophages, immune signaling,
immunoassays, glial biology, and (3) Proteomics, bioinformatics and systems biology. I will receive research
mentorship through weekly and monthly interactions and direct oversight of my research progress,
presentations at journal clubs, seminars and presentations at local and national meetings. I will also receive
formal coursework in glial biology, immunology, advanced methods in neuroscience research, bioinformatics,
R programing, systems biology (WeiGhted Correlation Network Analysis) and in the responsible conduct of
research (>12 credit hours and in-person training that fulfils NIH requirements) at Emory University. A team of
intra- and extra-mural contributors with expertise in systems biology, peptide synthesis, potassium channel
biology and biostatistics will also guide the proposed research. Emory University is a large academic institution
with Neuroscience and Neurology receiving one of highest research funding from the NIH (9th in the US). The
Emory Center for Neurodegenerative Diseases (CND) is a collaborative and cross-disciplinary research
environment with shared laboratory and research resources supported by NIH-funded research core facilities
in neuropathology, proteomics, multiplexed immunoassays, flow cytometry, cell imaging and rodent
neurobehavioral methods.
Research
Disease-modifying therapies are lacking for Alzheimer’s disease (AD), the most common cause of dementia
worldwide. Immune responses mediated by mononuclear phagocytes (MPs) in AD and othe...

## Key facts

- **NIH application ID:** 9977290
- **Project number:** 5K08NS099474-05
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Srikant Rangaraju
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $188,652
- **Award type:** 5
- **Project period:** 2016-09-30 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977290

## Citation

> US National Institutes of Health, RePORTER application 9977290, Microglial and macrophage potassium channels as regulators of neuroinflammation in Alzheimer's Disease (5K08NS099474-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9977290. Licensed CC0.

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