# Neuropathology Core

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $368,137

## Abstract

Project Summary – Neuropathology Core (NPC)
The Neuropathology Core (NPC) provides technical resources, laboratory facilities and professional expertise
for the collection, diagnosis and storage of tissue obtained at autopsy from patients with dementia and control
subjects studied in the Indiana Alzheimer Disease Center Clinical Core, other Alzheimer disease (AD) centers
(ADCs), the frontotemporal dementia (FTD) project of the NINDS, Dominantly Inherited Alzheimer Network
(DIAN) and academic institutions as well as families from the community including those referred by the
Alzheimer's Association chapters. The Neuropathology Core will provide information about pathologic data to
referring physicians and families as well as well-characterized tissue to basic researchers. In addition, the Core
will be involved in continuing education to physicians, researchers, technicians and the community about new
developments emerging from AD research. The understanding of the clinical, pathologic and molecular
aspects of AD and other dementias has advanced rapidly. Brain tissue of demented individuals must be
studied for diagnostic and research purposes using a multidisciplinary approach. The NPC has expanded our
mission integrating molecular technology to assist in the neuropathologic diagnosis. The NPC combines data
obtained by neurohistology, immunohistochemistry and immunocytochemistry to recognize and characterize
the localization and the antigenic profile of molecules that are important to the pathogenesis of dementia.
These studies carried out in parallel with molecular analysis are fundamental to understand disease etiology
and phenotypic heterogeneity. This multidisciplinary approach to be the hallmark of the IADC Neuropathology
Core and will aid us in providing a definitive diagnosis of dementing disorders. The NPC supports a large
number of national and international scientists with frozen and fixed samples from the tissue repository.
Results from studies carried out by investigators of the NPC are presented at numerous national and
international conferences, including the annual Alzheimer Association International Conference. The NPC
interacts with the Clinical Core, Neuroimaging Core and Genetics and Biomarkers Core to study patients
applying concepts of precision medicine.

## Key facts

- **NIH application ID:** 9977798
- **Project number:** 5P30AG010133-30
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** BERNARDINO Francesco GHETTI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $368,137
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977798

## Citation

> US National Institutes of Health, RePORTER application 9977798, Neuropathology Core (5P30AG010133-30). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/9977798. Licensed CC0.

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