# Vaccine induced memory immunity in tuberculosis

> **NIH NIH R01** · COLORADO STATE UNIVERSITY · 2020 · $380,000

## Abstract

PROJECT SUMMARY
The purpose of this R01 application is to investigate whether memory immunity induced in mice after
vaccination with different types of candidates [rBCG, protein fusion in adjuvant, live attenuated mutant] induce
similar or different subsets of CD4 memory T cells. Then, in a second series of studies, we will determine if this
makes any difference if the vaccinated animal is then infected with newly emerging virulent clinical isolates of
Mycobacterium tuberculosis which we have recently demonstrated differ in terms of their fitness, as well as
their capacity to elicit regulatory T cells capable of interfering with protective immunity. These are practical
issues in the field that are, as yet, not being addressed. Most of the proposed studies will be performed in the
Flow Cytometry Core facility within our Level-III building at CSU [the PI is the Director] and will employ flow
cytometry and high speed cell sorting, as well as our more usual highly standardized animal modeling
techniques. Even if we do not see major differences in terms of the overall generation of memory T cell
responses, the study outcomes may still reveal which type of vaccine “works best” [such head to head studies
have not been done as yet, and this may spur the field to use these approaches to better prioritize current
candidates].

## Key facts

- **NIH application ID:** 9977912
- **Project number:** 5R01AI127475-04
- **Recipient organization:** COLORADO STATE UNIVERSITY
- **Principal Investigator:** Marcela I Henao-Tamayo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $380,000
- **Award type:** 5
- **Project period:** 2017-08-10 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977912

## Citation

> US National Institutes of Health, RePORTER application 9977912, Vaccine induced memory immunity in tuberculosis (5R01AI127475-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9977912. Licensed CC0.

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