# Protein Production and Biochemical Characterization Core

> **NIH NIH P50** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $208,145

## Abstract

Protein Core Abstract
High quality proteins are essential for the success of structural studies. The Protein Core will support any PCHPI-
initiated projects and collaborators by producing milligram quantities of homogeneous recombinant viral
protein, human cellular proteins and their complexes for structural studies. The Core will also carry out
biophysical and bioanalytical characterization of proteins and protein complexes to support and validate
structural studies. To that end the Core will work in an iterative fashion with the NMR Core to generate proteins
suitable for structural studies and will provide protein and complexes to the X-ray Core and Cryo-EM Core for
screening and structure determination. The Core will also communicate on a regular basis with the Interactions
Discovery Core and HIV Virology Core, which together will provide information to the Protein Core on the
discovery of novel target proteins and/or their validation, thus getting new complexes ready to enter the structure
determination pipeline. Finally, the Core will support all Projects by making proteins for project goals.

## Key facts

- **NIH application ID:** 9977942
- **Project number:** 5P50AI150481-14
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** jinwoo ahn
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $208,145
- **Award type:** 5
- **Project period:** 2007-08-27 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977942

## Citation

> US National Institutes of Health, RePORTER application 9977942, Protein Production and Biochemical Characterization Core (5P50AI150481-14). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9977942. Licensed CC0.

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