# NMR Screening and Structural Characterization Core

> **NIH NIH P50** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $267,315

## Abstract

NMR Core Abstract
The PCHPI NMR Core has four specific aims: 1) Screen recombinant proteins to evaluate their biophysical
properties, structural integrity and determine their suitability for further structural determinations. 2) Screen
HIV proteins for putative/proposed interactions with host proteins; 3) Carry out NMR mapping of interfaces;
and 4) Determine solution structures of complexes, identified through screening. The Core will also carry out
studies that are integrated into Project 6, in particular elucidation of the interactions between Vpr and DNA
repair proteins, and will contribute on Projects 1 and 2 and the Technology Development Program 2. The NMR
Core will work in an iterative fashion, with the Protein Core, facilitating the generation of well-folded, stable
complexes for structure determination by NMR spectroscopy and/or X-ray crystallography.

## Key facts

- **NIH application ID:** 9977943
- **Project number:** 5P50AI150481-14
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** ANGELA M. GRONENBORN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $267,315
- **Award type:** 5
- **Project period:** 2007-08-27 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977943

## Citation

> US National Institutes of Health, RePORTER application 9977943, NMR Screening and Structural Characterization Core (5P50AI150481-14). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9977943. Licensed CC0.

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