# Cryo-Electron Microscopy and Tomography Core

> **NIH NIH P50** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $297,351

## Abstract

Cryo-EM Core Abstract
The Cryo-EM Core will be an important component of the PCHPI structure determination pipeline, playing a
major role in Project 1 and significantly contributing to Projects 2, 3 and 4, and tackling new HIV-host protein
complexes as they become available. The Core will screen complexes produced in the Protein Core or by
collaborators for their suitability for Cryo-EM or Cryo-ET structure determination and will determine the
structures of HIV-host protein complexes at atomic or near-atomic resolution, using single particle
methodologies. In addition, the Cryo-EM Core will develop methods to analyze structural heterogeneity within
samples, an issue that complicates current EM-based analytical approaches.

## Key facts

- **NIH application ID:** 9977948
- **Project number:** 5P50AI150481-14
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Peijun Zhang
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $297,351
- **Award type:** 5
- **Project period:** 2007-08-27 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977948

## Citation

> US National Institutes of Health, RePORTER application 9977948, Cryo-Electron Microscopy and Tomography Core (5P50AI150481-14). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977948. Licensed CC0.

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