# Administrative Core

> **NIH NIH P30** · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2020 · $234,738

## Abstract

Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of
the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster
of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical
Research Excellence (COBRE) at the Pennington Biomedical Research Center is leading an
effort to enhance research on metabolic disease by mentoring our most promising young
scientists to independence by senior scientists within the Center. The scope of work undertaken
by COBRE scientists encompasses a combination of cellular, molecular, and translational
approaches to address questions ranging from neural mechanisms of glucose sensing and
energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic
programming in obesity, regulation of mitochondrial biogenesis in adipocytes, and the role of
inflammation in pancreatic beta cell function. Our COBRE has developed the scientific
infrastructure to support the pursuit of these diverse objectives by establishing state of the art
Genomics, Cell Biology and Bioimaging, and Transgenic Cores. The Specific Aims of our
COBRE in Phase III are to further expand the critical mass of productive investigators engaged
in obesity/diabetes research by (a) develop and retain outstanding new junior faculty from within
the institution and mentor them to sustainable independent funding (b) recruit outstanding junior
and senior faculty engaged in metabolic disease research that complement existing strengths of
Center investigators; (c) develop and foster new opportunities for collaborative interactions with
institutional colleagues by instituting a new Pilot and Feasibility funding program, (d) enhance
utilization of the outstanding research infrastructure developed within the Cell Biology and
Bioimaging, Genomics, and Transgenic core facilities in Phase III through development of
training modules and outreach activites. The critical metrics of success are to expand the
number of extramural grants obtained by the COBRE faculty, increase the number of faculty
engaged in metabolic diseases research, leverage COBRE support to expand the quality of our
scientific cores through increased utilization and investment of institutional resources.

## Key facts

- **NIH application ID:** 9978090
- **Project number:** 5P30GM118430-05
- **Recipient organization:** LSU PENNINGTON BIOMEDICAL RESEARCH CTR
- **Principal Investigator:** Thomas W Gettys
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $234,738
- **Award type:** 5
- **Project period:** 2016-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978090

## Citation

> US National Institutes of Health, RePORTER application 9978090, Administrative Core (5P30GM118430-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9978090. Licensed CC0.

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