# UC Davis Alzheimer's Disease Core Center

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $1,573,469

## Abstract

PROJECT SUMMARY/ABSTRACT - OVERALL
The principal aim of the UC Davis ADC (UCD ADC) is to measure trajectories of cognitive change and
transition to dementia among a carefully studied and highly diverse subject cohort in order identify modifiable
risk and protective factors with the ultimate goal of developing novel interventions to improve cognitive health
and prevent dementia. This principal aim is accomplished through recruitment, maintenance and longitudinal
follow up to autopsy of a cohort of subjects from both community and clinical referral sources that varies along
the spectrum of cognitive ability, race/ethnicity, educational achievement, social economic status, spoken
language and degrees of medical comorbidity. To accomplish this principal aim, the UCD ADC utilizes six
highly integrated resource cores and a research education component to create a strong research
infrastructure while emphasizing a highly collaborative environment to facilitate novel research efforts,
education and training. In addition, UCD ADC encourages researcher diversity through the newly developed
Latino Aging Research Resource Center (LARRC) a NIA Resource Center in Minority Aging Research
(RCMAR) program. This highly diverse and predominantly cognitively normal cohort was developed to pursue
four major scientific themes: 1) identify the earliest clinical and biological evidence of age-related dementing
diseases, 2) identify and evaluate protective factors with emphasis on developing strategies to increase
cerebral reserve or resistance to age-related degenerative diseases, 3) examination of the impact of mixed
pathological processes on cognitive decline and conversion to dementia and 4) discovery and evaluation of
biological markers of cognitive health or decline. In line with the pressing need to develop novel clinical
therapeutics for AD, the UCD ADC also has begun to support investigator sponsored therapeutic studies.
This work, performed in a highly collaborative and inclusive environment that fully utilizes the unique resources
of the UC Davis environment and the skills of our collaborators, not only aims to advance new scientific
knowledge, but also encourages new and innovative research, improved clinical diagnoses, training, patient
and community education and superb data management and data sharing to leverage ongoing activities of the
UCD ADC to the wider research and educational community.
To obtain these objectives, the overall specific aims of the UCD ADC are to:
Provide an environment and core resources to enhance cutting-edge research as well as encouraging
extensive use of these resources by basic science, biomedical, behavioral, social and clinical investigators.
Manage these resources ethically, responsibly and efficiently through a well-established and highly effective
administrative structure that seeks to foster new and innovative areas of research and treatments.
Provide investigators and research groups with a unique resource of well-chara...

## Key facts

- **NIH application ID:** 9978555
- **Project number:** 5P30AG010129-30
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Charles DeCarli
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,573,469
- **Award type:** 5
- **Project period:** 1997-07-15 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978555

## Citation

> US National Institutes of Health, RePORTER application 9978555, UC Davis Alzheimer's Disease Core Center (5P30AG010129-30). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9978555. Licensed CC0.

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