# University of Kansas Alzheimer's Disease Core Centers

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2020 · $1,959,775

## Abstract

PROJECT SUMMARY: OVERALL
 The University of Kansas Alzheimer's Disease Center (KU ADC) promotes research into Alzheimer's
disease (AD), brain disorders relevant to AD, and brain aging. We provide support, services, datasets, and
biospecimens to institutional, regional, national, and international investigators.
 The KU ADC transforms AD-relevant research at our home institution and is an indispensable part of the
KU neuroscience landscape. We benefit from and enhance an institutional T32 program, receive regular
support from an institutional neuroscientist training fund, work closely with KU departments on neuroscientist
faculty recruitment, and are a key component of the KU Institute for Neurologic Discoveries (KU IND). We
further maintain interactive collaborations with other KU entities including the KU Landon Center on Aging
(LCOA), Clinical Translational Science Award (CTSA) Center, NeuroNext site, and KU Cancer Center. We
create AD-related clinical and educational infrastructure, making us a vital community and regional set-piece.
 While the KU ADC promotes an array of AD research, a prominent Center objective is to support, promote,
and advance studies that address the causes and consequences of altered energy metabolism in aging and
AD. Changes in energy metabolism (i.e, bioenergetics) have been linked to brain aging and AD. The KU ADC
has developed a unique infrastructure that enables innovative research pertinent to basic, translational, and
clinical energy metabolism-relevant questions. We are uniquely positioned to explore how altered energy
metabolism contributes to brain aging and AD, and test the therapeutic potential of energy metabolism
manipulations for the treatment of AD. We currently support state of the art programs that are testing the
effects of physical exercise and dietary interventions on brain health, developing pharmacologic approaches to
manipulate brain energy metabolism, exploring the contribution of mitochondrial genes to AD, and validating
mitochondrial and other energy metabolism-related biomarkers. By advancing our understanding of energy
metabolism's role in AD at multiple levels, developing novel capabilities, and testing innovative approaches
intended to measure, characterize, and treat AD energy metabolism dysfunction we address a critical AD
knowledge gap and position ourselves to potentially shift current AD research and clinical practice paradigms.
 Our first funding cycle (2011-16) focused on Center infrastructure, and our second funding cycle will extend
our portfolio of federally funded investigator projects to further complement the first class, innovative research
programs we currently support. Through these efforts and the research infrastructure we provide, we will
pursue our mission to develop interventions that can prevent and treat AD. We will accomplish these goals
through the following Specific Aims: (1) Advance AD and brain aging research; (2) Serve as a Midwestern hub
for AD research, clini...

## Key facts

- **NIH application ID:** 9978557
- **Project number:** 5P30AG035982-10
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** RUSSELL H. SWERDLOW
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,959,775
- **Award type:** 5
- **Project period:** 2011-08-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978557

## Citation

> US National Institutes of Health, RePORTER application 9978557, University of Kansas Alzheimer's Disease Core Centers (5P30AG035982-10). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9978557. Licensed CC0.

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