# Core D: Neuropathology Core

> **NIH NIH P30** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2020 · $187,685

## Abstract

ABSTRACT: NEUROPATHOLOGY CORE
 The Neuropathology Core (NPC) coordinates and carries out the technical procedures related to the
neuropathologic tissue-based studies that are essential to the University of Kansas Alzheimer Disease Center
(ADC) study subjects enrolled in the Clinical Core. The Core neuropathologist oversees the pathologic
examination of the brain and prepares a diagnostic report for the family, physicians, and the National
Alzheimer's Coordinating Center. The NPC prepares the brain tissue in a systematic way, using standardized
protocols and diagnostic criteria, in order to facilitate good correlations among other ADCs, and to maximize
research potential. In addition, to the brain we also collect muscle and skin biopsies, if the family agrees.
 The brain tissue collection is coded to protect privacy, organized, monitored, and safeguarded. As the KU
ADC Study is still relatively young, we have a small number of cases in our repository, but we already have
many researchers who are interested in obtaining brain tissue. The Core provides neuropathologic
professional and technical expertise about AD/other neurodegenerative disease on an individualized basis to
researchers.
 The NPC personnel frequently communicate with family members of Clinical Core participants or others
outside of the study who are interested in our program. We place high value on education and hold teaching
conferences and presentations where we educate physicians, nurses, and trainees about Alzheimer disease,
other dementias, and aging. We have a growing interest in the correlation of neuroimaging and neuropathology
findings. Toward that goal, we have a neuroradiologist consultant who helps in teaching about brain MR
imaging.
 To contribute to national and international research studies of AD and related disorders, we assist in
autopsies of subjects who have enrolled in studies, such as Alzheimer's Disease Neuroimaging Initiative
(ADNI), and the Dominantly Inherited Alzheimer Network (DIAN.)
 Because of our ADC's focus on metabolic disease, the NPC Core is working with a consultant who is an
expert in the use of a unique imaging technique that has been used to detect metabolic changes in brain. We
hope this approach may lead to new information about the brain metabolism in AD and/or aging.

## Key facts

- **NIH application ID:** 9978595
- **Project number:** 5P30AG035982-10
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** Kathy L Newell
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $187,685
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978595

## Citation

> US National Institutes of Health, RePORTER application 9978595, Core D: Neuropathology Core (5P30AG035982-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9978595. Licensed CC0.

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