# Developmental Determinants of Cardiovascular Disease

> **NIH NIH T32** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $532,197

## Abstract

This is the first renewal of the T32 application from Division of Pediatric Cardiology, Vanderbilt University
School of Medicine. By advancing a program that integrates formal training in research on developmental
determinants of cardiovascular disease with clinical training in pediatric cardiology, we will provide a unique
training environment that will foster development of academic pediatric cardiologists. This training program will
not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the
impact of pre- and postnatal development in defining the manifestations of cardiovascular pathology after birth.
In addition to trainees in the Pediatric Cardiology, clinical or Ph.D. post-doctoral fellows who have an
expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for
support. We are requesting continued support for 3 trainees / year for two years for a total of 6 trainees / year
for a five year period. This program will provide a unique opportunity for trainees to study the recapitulation of
normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or
adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic
science investigation or (2) clinical or translational research. A focused, mentored, laboratory experience with
targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career.
For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical
Investigation (MSCI) program will be an integral part of the training program. Candidates will be identified from
the pool of applicants applying for a pediatric cardiology fellowship (112 applicants for 3 positions in 2017) as
well as from talented clinical and post-doctoral fellows throughout Vanderbilt University. During a first clinical
year of pediatric cardiology fellowship (PGY-4) the candidates will be matched with mentors and together, they
will decide upon a research project. During the second and third years of a four year fellowship, trainees will
carry out a mentored research project. During the fourth year, the trainee will complete clinical training with the
option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or
K23 application. This grant will provide support for the second and third years of protected research training.
The Department of Pediatrics is committed to complete support of fellows during the first and fourth years as
well as supplementing support provided by this grant in years two and three. Using the unique strengths of
Vanderbilt University in the areas of cardiac development and regeneration, myocardial biology, pulmonary
biology and pulmonary hypertension, cardiovascular genetics and pharmacogenomics, vascular biology and
atherosc...

## Key facts

- **NIH application ID:** 9978596
- **Project number:** 5T32HL105334-10
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** H Scott Baldwin
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $532,197
- **Award type:** 5
- **Project period:** 2011-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978596

## Citation

> US National Institutes of Health, RePORTER application 9978596, Developmental Determinants of Cardiovascular Disease (5T32HL105334-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9978596. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*