# Role of the microbiome in HIV vaccine induced heterogeneity

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $504,977

## Abstract

The incredible diversity and abundance of the human microbiome has only come to light
in the last decade. The scientific community has learned that the gut microbial
ecosystem has a major role in the development and homeostasis of the immune
system. Our team wants to learn how these systems communicate to shape HIV
vaccine immune responses. We are interested in how the microbiome shapes immune
responses to HIV vaccines and contributes to vaccine response heterogeneity. We have
a special emphasis on investigating the durability and class of antibodies that are
elicited by different vaccines and the cellular responses that may contribute to these
humoral endpoints, and how specific microbiota may contribute to these different
responses. We will conduct correlates analyses with clinical and mouse microbiome and
immunogenicity data; we will unravel mechanisms of immunity by perturbation of the
immune system and the microbiome — the immune system via multiple adjuvanted
immunization regimens and the microbiome by gut microbial reconstitution in germ free
mice; and we will conduct metabolomics case-control analyses from select human and
mouse samples. The knowledge gained in the end will shed light on the mechanisms of
how vaccines work and may improve vaccines by way of novel adjuvant discovery.

## Key facts

- **NIH application ID:** 9978668
- **Project number:** 5R01AI127100-05
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** James G. Kublin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $504,977
- **Award type:** 5
- **Project period:** 2016-09-27 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978668

## Citation

> US National Institutes of Health, RePORTER application 9978668, Role of the microbiome in HIV vaccine induced heterogeneity (5R01AI127100-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9978668. Licensed CC0.

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