# 7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder

> **NIH NIH K01** · AUBURN UNIVERSITY AT AUBURN · 2020 · $161,971

## Abstract

PROJECT SUMMARY / ABSTRACT
This Mentored Research Scientist Development Award (K01) application is a comprehensive training plan to
provide the candidate with additional and advanced skills needed to establish an independent program of post-
traumatic stress disorder (PTSD) research using neuroimaging methods. The candidate’s prior training in
neuroimaging has allowed her to hone many skills necessary to achieve this goal. However, she requires
additional training and experience in the following areas: (1) didactic and research training in PTSD; (2)
advanced techniques in high-field (7T) MR spectroscopy (MRS), specifically functional MRS (fMRS); (3)
programming skills for neuroimaging analyses; and (4) writing and professional development. The proposed
study will investigate the neurometabolic and functional correlates of cognitive deficits in PTSD. People with
PTSD commonly report difficulties with concentration, attention, and memory in addition to the core symptoms
of intrusive thoughts, avoidance, and hyperarousal. These cognitive symptoms can be especially distressing
and lead to poor social and occupational function and poor quality of life. Neuropsychological testing indicates
that working memory (WM) is one cognitive process affected in PTSD, yet the neural basis of WM dysfunction
is not well understood. Understanding the nature of these deficits is important not only because WM is crucial
for everyday functioning but also because WM facilitates common treatment strategies, such as cognitive
behavioral therapy. Converging evidence points to glutamatergic dysfunction in key brain regions in PTSD.
These abnormalities could underlie the differential activation patterns observed with functional imaging when
people with PTSD perform WM tasks; however, this has not been directly tested. Magnetic resonance
spectroscopy (MRS) has demonstrated great promise in closing this gap with recent in vivo studies of PTSD
showing disruptions of glutamate levels. However, none of these studies have correlated these in vivo
metabolic measurements with neural activation. Functional MRS (fMRS) can potentially address this issue by
measuring neurometabolic changes induced by neural activity in response to stimuli. Unlike traditional MRS,
which acquires data during the resting state, fMRS acquires data while participants are engaged in performing
a task, thereby providing a dynamic rather than static profile of neurometabolites. In this application, we
propose to develop fMRS techniques at 7T to explore the neural mechanisms that contribute to WM deficits in
PTSD. This research will combine traditional (static) MRS, functional MRI (fMRI), and advanced dynamic fMRS
to investigate the relationship between neural activation during WM and the underlying neurochemistry in
PTSD. Since fMRS and fMRI probe different aspects of neuronal firing and synaptic activity, the combined
approach of these techniques could better characterize the neurobiology underlying WM deficits...

## Key facts

- **NIH application ID:** 9978908
- **Project number:** 5K01MH115272-03
- **Recipient organization:** AUBURN UNIVERSITY AT AUBURN
- **Principal Investigator:** Meredith A Reid
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $161,971
- **Award type:** 5
- **Project period:** 2018-08-15 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9978908

## Citation

> US National Institutes of Health, RePORTER application 9978908, 7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder (5K01MH115272-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9978908. Licensed CC0.

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