# Disparities in glycated hemoglobin during and beyond pregnancy in a population-based cohort of women with gestational diabetes

> **NIH NIH R21** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $211,875

## Abstract

PROJECT SUMMARY
Gestational diabetes (GDM) is a common complication of pregnancy with substantial disparities between
racial/ethnic and immigrant groups.
diabetes
on
contribute
Women with GDM are at an increased risk of later developing Type 2
(T2DM), and data on disparities in T2DM following GDM suggest the greatest effect of GDM
the transition to T2DM in black and Hispanic women. Thus GDM disparities are critical because they could
to lifecourse T2DM disparities.
limited
GDM has the potential to be an early warning system for T2DM and
therefore is an opportunity to intervene to reduce T2DM disparities in women. Unfortunately, this opportunity is
often missed due to inadequate long-term follow-up. Glycosylated hemoglobin (HbA1C) is a well-established
diagnostic tool for T2DM, with recommended guidelines for diagnosis and control of T2DM. However, data is
scarce about prevalence and predictors of long-term HbA1c screening following GDM, and population-based
measures of HbA1c levels during and beyond pregnancy. Further, influence of race/ethnicity and nativity on
these measures has not been adequately investigated. A major barrier to filling this gap is the lack of a large,
diverse GDM cohort with valid outcome measures. We propose a secondary data analysis using linked birth
certificate, hospital discharge, and HbA1c registry data from the years 2009-2017 to construct a population-
based retrospective cohort. In this novel pregnancy cohort, we aim to: 1) Characterize HbA1c profiles
prenatally and through eight years postpartum in women with and without gestational diabetes, overall and by
race/ethnicity/nativity; 2) Among women with a GDM pregnancy, determine racial/ethnic/nativity and
socioeconomic disparities in long-term HbA1c testing up to eight years postpartum; 3) Among women with a
GDM pregnancy, measure racial/ethnic/nativity disparities in longitudinal T2DM outcomes (T2DM and glucose
control) and examine prenatal HbA1c levels and clinical characteristics of pregnancy as predictors of poor
outcomes. Discoveries of disparities in long-term screening and T2DM outcomes over 8 years of follow-up will
guide future interventions to use GDM as a lever to prevent lifecourse T2DM disparities.

## Key facts

- **NIH application ID:** 9979548
- **Project number:** 1R21DK122266-01A1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Teresa Janevic
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $211,875
- **Award type:** 1
- **Project period:** 2020-03-11 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9979548

## Citation

> US National Institutes of Health, RePORTER application 9979548, Disparities in glycated hemoglobin during and beyond pregnancy in a population-based cohort of women with gestational diabetes (1R21DK122266-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9979548. Licensed CC0.

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