# Chronic Renal Insufficiency Cohort (CRIC) Study

> **NIH NIH U01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $592,390

## Abstract

ABSTRACT
Between 2001-2018, the NIDDK sponsored Phases I, II and III of the Chronic Renal Insufficiency Cohort
(CRIC) Study in which approximately 3,939 multiethnic, adult participants were enrolled from seven clinical
centers and their satellites, along with 1560 patients who were older with milder chronic kidney disease (CKD).
An additional 326 participants of Hispanic ethnicity with chronic kidney disease (CKD) were recruited from one
clinical center The cumulative total of 5,499 study participants has been followed for 2-14 years during which
we aimed to: (1) examine the risk factors for CKD progression and cardiovascular disease (CVD); (2) study the
relationship between CKD and outcomes in the elderly; (3) evaluate the CKD and CVD outcomes in
participants with CKD stage 2 and 3 A (mild/moderate CKD); (4) develop predictive models to identify high risk
subgroups; and (5) identify biomarkers which predict disease progression and complications. The goals of the
current proposal are to: (1) continue the follow-up of the originally recruited CRIC cohort; (2) study the
relationship between sub clinical acute declines in kidney function and CKD outcomes; (3) Conduct a
comprehensive assessment of the morbidity experienced by participants with CKD including CVD clinical
outcomes by the use of remote data capture.
In CRIC 2018-2023, the Michigan CRIC Clinical Center will undertake the following specific aims:
 1. To re-enroll a high percentage of existing participants into CRIC 2018 and obtain clinical center-based
 assessments (questionnaires, physical measurements, biological specimens) in study participants.
 2. To maintain high levels of participant retention during CRIC 2018.
 3. To identify novel cardiovascular phenotypes using remotely collected cardiovascular function and
 determine their relationship to clinical outcomes.
 4. To examine sub-clinical acute declines in kidney function using remotely collected kidneys function
 outside of the clinical center and determine their relationship to clinical outcomes.
 5. To investigate self-reported cardiovascular and renal events and obtain supporting medical records and
documentation.
 6. To implement effective local quality assurance and quality control procedures to ensure standardized
 high-quality measurements.
 7. To participate in governance and oversight of CRIC through study-wide subcommittees and activities
 8. To publish and present findings from the CRIC Study, including integrative and other high-impact
 manuscripts, as chairs and members of CRIC writing groups.
 9. To conduct approved CRIC ancillary studies at the Michigan Clinical Center.
 10. To facilitate state-of-the-art methods in biostatistics and bioinformatics to analyze complex, longitudinal
 datasets incorporating a multitude of exposure and outcome variables to produce integrated papers.
 11. To engage investigators at the University of Michigan Health Systems, to assist in the local analysis of
 CRIC data, to develop and co...

## Key facts

- **NIH application ID:** 9979641
- **Project number:** 5U01DK061028-20
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Panduranga S Rao
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $592,390
- **Award type:** 5
- **Project period:** 2001-09-28 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9979641

## Citation

> US National Institutes of Health, RePORTER application 9979641, Chronic Renal Insufficiency Cohort (CRIC) Study (5U01DK061028-20). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9979641. Licensed CC0.

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