# Molecular function of Myosin-l

> **NIH NIH R37** · UNIVERSITY OF PENNSYLVANIA · 2021 · $529,509

## Abstract

Program Director/Principal Investigator (Last, First, Middle): Ostap, E. M.
SENIOR/KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below.
Start with Program Director(s)/Principal lnvestigator(s). List all other senior/key personnel in alphabetical order, last name first.
Name eRA Commons User Name Organization Role on Project
E. M. Ostap Ostapm University of PA Pl
Roberto Dominguez Dominguez University of PA Investigator
Henry Shuman shuman University of PA Investigator
Charles Sindelar Csindelar Yale University Consortium Pl
OTHER SIGNIFICANT CONTRIBUTORS
Name Organization Role on Project
Human Embryonic Stem Cells Ii] No Dves
If the proposed project involves human embryonic stem cells, list below the registration number of the specific cell line(s) from the following list:
https://grants.nih.gov/stem cells/registry/current.htm. Use continuation pages as needed.
If a specific line cannot be referenced at this time, include a statement that one from the Registry will be used.
Cell Line
 0MB No. 0925-0001
PHS 398 (Rev. 01/18 Approved Through 03/31/2020)
 Page] Form Page 2-continued
 Number the following pages consecutively throughout
 the application. Do not use suffixes such as 4a, 4b.
 BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
 Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: E. Michael Ostap
eRA COMMONS USER NAME (credential, e.g. , agency login): OSTAPM
POSITION TITLE: Professor of Physiology and Director of the Pennsylvania Muscle Institute
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
DEGREE Completion
(if Date
applicable) MMNYYY
Illinois State University, Normal IL
University of Minnesota, Minneapolis, MN
B.S. 05/1988
Ph .D. 09/1993
Johns Hopkins University School of Medicine,
Baltimore MD
Post-doc 12/1996
FIELD OF STUDY
Chemistry
Biochemistry,
Molecular Biology, &
Biophysics
Biochemistry & Cell
Biology
A. Personal Statement
I have a strong background in the investigation of the biochemistry and biophysics of cytoskeletal motors. I
have developed and utilized advanced biophysical & biochemical techniques (ensemble and single-molecule).
I was the first to characterize the detailed ATPase kinetic mechanism of an "unconventional" myosin motor,
and my laboratory has been a leader in the characterization of the force-dependent kinetics of muscle and non-
muscle myosins. Much of our recent focus has been on the use of single-molecule and structural methods to
investigate myosin-I motors, where we described the biophysics of membrane binding and the relationship
between their mechanical and biochemical activities. Our recent work resulted in the determination of the
structural mechanism of myosin force-...

## Key facts

- **NIH application ID:** 9980029
- **Project number:** 4R37GM057247-23
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** E. Michael Ostap
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $529,509
- **Award type:** 4C
- **Project period:** 1998-08-01 → 2025-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980029

## Citation

> US National Institutes of Health, RePORTER application 9980029, Molecular function of Myosin-l (4R37GM057247-23). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9980029. Licensed CC0.

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