# Michigan Alzheimer's Disease Core Center

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $2,118,485

## Abstract

OVERALL
Abstract
The Michigan Alzheimer’s Disease Core Center (Michigan ADCC) aims to foster and enhance innovative
research in Alzheimer’s disease (AD) and related dementias with a long term goal of developing targeted
therapies for these challenging disorders. This center will build on the existing deep infrastructure and research
strengths in dementia and aging research at the University of Michigan (UM). The Michigan ADCC will
emphasize research that seeks to identify, understand, and modulate the non-ß-amyloid factors that contribute
to brain dysfunction and neurodegeneration in AD and other dementias. The rationale for this focus is that
while recent advances have defined a central role for ß-amyloid in AD, many potentially modifiable factors
beyond ß-amyloid contribute to brain dysfunction and degeneration yet remain poorly understood. The
Michigan ADCC will leverage established strengths in brain imaging, dementia risk identification and
disclosure, mechanistic studies of neurodegenerative proteinopathies, and predictive Big Data analytics to
achieve this objective. A truly regional center, the Michigan ADCC will promote research across the UM
campus, throughout the state of Michigan via collaborations with our partner universities Michigan State
University and Wayne State University, and across the nation through collaborations with other NIA-sponsored
AD Centers (ADCs) and programs. The Michigan ADCC has four goals: 1) Foster, catalyze and perform
research of the highest potential impact in AD and related neurodegenerative disorders; 2) Promote regional
efforts to understand, diagnose and treat AD and related dementias through collaborative scientific and
outreach efforts; 3) Provide a wide range of training and research opportunities in the dementias for health
care professionals, scientists, and students through innovative educational and mentoring efforts; and 4)
Collaborate with other ADCs, the NACC, and other multi-center research efforts to move the field closer to
effective therapies for this group of devastating diseases. Success in achieving these goals will be ensured
through the fully integrated activities of six cores (Administrative; Clinical; Data Management and Statistical;
Neuropathology; Outreach and Recruitment; and Research Education Component ), and through close
collaboration with related programs including the UM Protein Folding Diseases Initiative, Claude D. Pepper
Older Americans Independence Center, Udall Center of Excellence for Parkinson’s Disease Research, and
Healthier Black Elders Center of the Michigan Center for Urban African American Aging Research. These and
other collaborations have led to newly developed emphases on the detection of early cognitive decline in an
underserved population (African Americans in Detroit) and on novel potential biomarkers of disease. The
Center’s extensive preliminary organization and teams of experts ensure that, upon receiving NIA designation,
the Michigan ADCC will have a...

## Key facts

- **NIH application ID:** 9980230
- **Project number:** 5P30AG053760-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Henry L Paulson
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,118,485
- **Award type:** 5
- **Project period:** 2016-08-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980230

## Citation

> US National Institutes of Health, RePORTER application 9980230, Michigan Alzheimer's Disease Core Center (5P30AG053760-05). Retrieved via AI Analytics 2026-06-15 from https://api.ai-analytics.org/grant/nih/9980230. Licensed CC0.

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