# Core D: Neuropathology Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $303,117

## Abstract

CORE D: NEUROPATHOLOGY CORE
Abstract
The Neuropathology Core (NC) will capitalize on the longstanding, actively recruiting University of Michigan
(UM) Brain Bank, several decades of patient clinical characterization by Alzheimer’s Disease (AD) researchers
at UM, and the substantial resources of the UM Protein Folding Diseases (PFD) Initiative to advance the
Michigan ADCC's central theme: to identify, understand and modulate the non-β amyloid factors contributing to
brain dysfunction and neurodegeneration in AD and related dementias. Studies of these diseases will be
facilitated by integrating NC, Clinical Core and Data Management and Statistical Core activities to collect and
properly characterize post-mortem material and associated antemortem biospecimens from ADCC participants
with no neurologic disease and those with varied stages of AD and related neurodegenerative disorders. The
NC will follow the 2014 NIA Biospecimen Task Force best practice guidelines for the evaluation, banking and
distribution of brain tissue, DNA, and plasma. These essential resources, along with access to NC expertise
and technologies, will be available for investigators at UM, our regional partner institutions Michigan State
University and Wayne State University, and AD Centers across the country. Furthermore, by leveraging
resources of the PFD Initiative and the diverse expertise of NC investigators in neurodegenerative
proteinopathies, the NC will be uniquely positioned to facilitate innovative research into the pathologic
mechanisms underlying protein dysfunction in dementia. To accomplish these goals and tasks, the NC will
pursue the following aims: 1) grow and maintain a brain bank with well-characterized frozen and fixed tissue, 2)
provide accurate, detailed, and standardized neuropathological evaluation, 3) distribute banked tissue and
biospecimens, 4) contribute neuropathologic data to NACC, 5) support researchers studying AD and related
dementias, and 6) actively educate trainees about the neuropathologic assessment of dementia. Through
these aims, the NC will greatly facilitate basic and translational studies of the dementias, expand the research
community actively engaged in this work, and help build new collaborations for future discoveries.

## Key facts

- **NIH application ID:** 9980249
- **Project number:** 5P30AG053760-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** ANDREW P LIEBERMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $303,117
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980249

## Citation

> US National Institutes of Health, RePORTER application 9980249, Core D: Neuropathology Core (5P30AG053760-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9980249. Licensed CC0.

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