# Using single-cell RNA-seq to interrogate host immunity to pathogens

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $557,572

## Abstract

Project Summary
 Mortality from infectious diseases remains a leading cause of death worldwide,
making the development of new vaccines an important priority of biomedical research.
Immunologic memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Traditional vaccination strategies are very effective at generating
neutralizing antibodies against bacteria and viruses. However, a vaccine capable of
generating robust T lymphocyte memory is still beyond our research, due, in part, to an
incomplete understanding of the molecular basis of lymphocyte fate specification. In this
proposal, we will develop single-cell approaches to study specification of lymphocyte
fates in response to microbial infection.

## Key facts

- **NIH application ID:** 9980269
- **Project number:** 5R01AI123202-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** John T Chang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $557,572
- **Award type:** 5
- **Project period:** 2016-09-23 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980269

## Citation

> US National Institutes of Health, RePORTER application 9980269, Using single-cell RNA-seq to interrogate host immunity to pathogens (5R01AI123202-05). Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/grant/nih/9980269. Licensed CC0.

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