# Genomics and Cell Biology Core

> **NIH NIH P30** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $207,797

## Abstract

Project Summary/Abstract
The overall goal of the Genomics & Cell Biology Core will be to facilitate the application of cutting-edge
genomics, bioinformatics, cell biology, and immunology techniques to nutrition and metabolic research. This
will be accomplished by combining the capabilities of the pre-existing NORC-H Genomics and Cell Biology
Cores, by encouraging multi-disciplinary approaches and collaborations to study nutrition-related topics, and by
overcoming the barrier of using complex and expensive techniques by providing appropriate training to NORC-
H Investigators. The guiding philosophy of the Genomics & Cell Biology Core is that although many projects
can be advanced by the use of sophisticated genomic and cell biology techniques, their expense and difficulty
of first use represent a significant barrier. The new combined Genomics & Cell Biology Core is specifically
designed to overcome this barrier by providing training to NORC-H investigators that is not typically available in
most NGS, genomics, bioinformatics, cell biology, or immunology core facilities. To maintain continuity and
high standards, the key personnel that have guaranteed the success of the previous Genomics and Cell
Biology Cores will remain the same, including the Core Director Dr. Fred Ausubel (who has been the Director
of Genomics Core since the original inception of the Center grant in 1994), Co-Associate Director
(Bioinformatics and Next Generation Sequencing) Dr. Ruslan Sadreyev, and Co-Associate Director (Cell
Biology) Dr. Haining Shi. In addition, Dr. Alessio Fasano, a renowned Celiac disease researcher, will serve as
overall Co-Core Director with Dr. Ausubel. There are 5 specific Aims: 1) provide consultative services related
to genomics, cell biology, and immunology research design; 2) provide space, technical personnel, and
specific training and supervision for utilizing specialized techniques and equipment used in cell biology,
immunology, and genomics research, including “nanoString”-based transcriptional profiling, assistance in the
development of high-content high-throughput assays using automated microscopic imaging, and fluorescent-
activated cell sorting; 3) provide a variety of genomics-related services related to next-generation sequencing;
4) provide bioinformatic analysis of various types of high-throughput data, including RNA-Seq, metagenomics,
ChIP-Seq, proteomics, microarray data, as well as computational analysis of molecular pathways, networks
and phenotypes; and 5) Conduct enrichment tutorials and workshops in basic concepts in genomic,
bioinformatic, cell biology, and nutrition and GI immunology-related techniques, and coordinate summer
internships for undergraduates and medical students. This will be accomplished through the extensive
expertise of the Core Directors and staff with the help of extensive instrumentation for bioinformatics analysis,
next generation sequencing, nanoString-based transcriptional profiling, automated microscopy ...

## Key facts

- **NIH application ID:** 9980370
- **Project number:** 5P30DK040561-24
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Frederick M Ausubel
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $207,797
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980370

## Citation

> US National Institutes of Health, RePORTER application 9980370, Genomics and Cell Biology Core (5P30DK040561-24). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980370. Licensed CC0.

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