# Islet Procurement and Research Core

> **NIH NIH P30** · STANFORD UNIVERSITY · 2020 · $188,610

## Abstract

Project Summary / Abstract (Islet Core)
The specialized islet biology expertise of the Islet Procurement and Research Core (IPRC) will provide SDRC
investigators with the capacity to perform modern molecular, cellular and functional studies of high-quality
islets and pancreata from rodents and humans. The SDRC's large group of collaborative investigators study a
broad spectrum of islet biology in physiological or pathological settings, including islet development, functional
maturation, maintenance of mature cell fate, proliferation, genetics, epigenetics, gene regulation, inter-organ
signaling, intra-islet cell signal transduction, islet immunology, and aging, to name a few. A central aspect of
the IPRC is our direct focus on parallel studies in rodent and human tissues. An essential component
supporting the majority of studies falling under this paradigm is our ability to isolate high-quality, well-
characterized rodent pancreatic islets, and then to perform assays of islet cellular, molecular and physiological
phenotypes. This is coupled with a reliable, robust programs in the IPRC to procure high-quality human islets
that have increased the number of SDRC investigators studying human islet biology. The support of
transplantation-based studies of human islet cell function, growth and fate by the IPRC will also enhance
potential translational studies of human islets for diabetes. In addition to these services, the IPRC is committed
to training investigators in specialized methods of islet biology, like islet isolation and transplantation, islet
culture and specialized assays including insulin ELISA, glucagon ELISA, perfusion and static batch insulin
secretion assays, and immunohistology. IPRC personnel will work closely with SDRC investigators to build
efficient experimental strategies tailored to their aims. The IPRC also serves the Stanford community of
science and the SDRC by continuously developing new experimental capacity to match the dynamic demands
of modern islet investigations. This includes assays of islet function, new approaches to investigate human islet
cell genetics, new models of islet transplantation, and assistance in developing new clinical islet programs at
the hospitals and clinics of Stanford Health Care. The IPRC also enhances the use of other Research Cores in
the Stanford DRC. Together with the Diabetes Immune Monitoring Core (DIMC) and the Diabetes Genomics &
Analysis Core (DGAC), the IPRC will integrate efforts permitting cellular, genetic, molecular, physiological and
genome studies of human pancreas- and islet-associated cells relevant to diabetes, including immune, stromal
and vascular cells. In summary, the Islet Procurement and Research Core will serve as an invaluable, novel
resource for the SDRC, providing investigators with the pancreas- and islet-specific expertise and training to
enable and expand their diabetes-related research.

## Key facts

- **NIH application ID:** 9980400
- **Project number:** 5P30DK116074-04
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Seung K Kim
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $188,610
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980400

## Citation

> US National Institutes of Health, RePORTER application 9980400, Islet Procurement and Research Core (5P30DK116074-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980400. Licensed CC0.

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