# Understanding the prefrontal mechanisms involved in the enhancement and maintenance of visual signals

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2020 · $380,000

## Abstract

Working memory and attention, both critical components of executive function and flexible, goal-
driven behavior, are jointly impaired in multiple cognitive disorders, including Parkinson's disease,
schizophrenia, and attention deficit hyperactivity disorder. Several decades of research have implicated
the prefrontal cortex (PFC) in the control of attention and working memory. In spite of recent evidence
indicating that the representation of visual information is modulated by the contents of working memory,
little is known about the neural mechanisms underlying this modulation. This project aims to achieve a
fundamental advance in our understanding of these mechanisms using very direct approaches:
identifying PFC neurons involved in reciprocal connections with visual cortex, measuring dynamic
changes in the strength of PFC inputs, and local pharmacological manipulations of neuronal activity. The
ability of neuroscientists to describe the neural mechanisms giving rise to cognitive functions has long
been hampered by the difficulty of combining anatomical and electrophysiological characterization of
neurons. Aim 1 will combine recent advances in online spike waveform discrimination, array recording,
and custom hardware to produce a highly efficient, semi-automated system for the screening of
connectivity between brain areas. This system will be developed in collaboration with data acquisition
hardware company Neuralynx, and provide neurobiologists a high-throughput tool to study the
connectivity of brain networks, significantly enhancing our ability to untangle functionally specific circuits.
This system will be used to examine communication between PFC and visual cortex during working
memory. Preliminary data indicate that working memory activity is the key characteristic of PFC neurons
projecting to visual cortex. Next, how visual responses change based on the contents of working memory
will be measured. Lastly, whether dopamine-mediated prefrontal activity is sufficient to drive these
changes in visual processing will be directly tested using localized drug infusions. Aim 2 examines the
impact of spatial activity in prefrontal cortex on the maintenance of an object memory in visual cortex,
and on memory performance. The contribution of dopaminergic prefrontal activity to the neural and
behavioral correlates of object working memory will be causally tested. Together, these aims will provide
a detailed mechanistic account of how the interactions between PFC and visual cortex depend upon the
contents of working memory; such an understanding will provide insight into the interdependence of
attention and working memory, and how working memory deficits are associated with impairments in the
processing of visual information, as is often observed in mental illnesses.

## Key facts

- **NIH application ID:** 9980417
- **Project number:** 5R01EY026924-05
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Behrad Noudoost
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $380,000
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980417

## Citation

> US National Institutes of Health, RePORTER application 9980417, Understanding the prefrontal mechanisms involved in the enhancement and maintenance of visual signals (5R01EY026924-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980417. Licensed CC0.

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