# Rational Integration of clinical SEquencing (RISE)

> **NIH NIH R01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $709,835

## Abstract

RISE Project Summary
The advent of clinical genome sequencing to identify patients at risk for serious diseases
and to tailor treatments promises to greatly improve health outcomes and provide a
foundation for the delivery of Precision Medicine. However, even as laboratory methods
to perform sequencing become highly efficient, uncertainty around the optimal breadth
and economic value of sequencing as well as ambiguity around which individuals should
be tested presents a critical barrier to wider use. As we rapidly approach an era of
inexpensive sequencing, new approaches to quantify and optimize the economic and
clinical value of genome-tailored care are needed. For the Rational Integration of
Sequencing (RISE) project, we propose to develop a Discrete Event Simulation (DES) to
estimate the average clinical efficacy and cost-effectiveness of prospectively acquiring
sequence data across a diverse patient population. The simulation will leverage
literature-based estimates of clinical outcome rates, costs, and utilities combined with
clinical exome and pharmocogenomic implementation program data describing how
results are returned and reacted to within clinical care. The first Aim will develop a
conceptual framework and computational infrastructure to understand the drivers of
economic value in genomic screening. The second Aim will externally validate the RISE
model using real-world use data. The third Aim will assess the cost effectiveness of
genomic screening scenarios, identify key drivers of value and inform research priorities
in genomic screening.

## Key facts

- **NIH application ID:** 9980443
- **Project number:** 5R01HG009694-04
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Jing Hao
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $709,835
- **Award type:** 5
- **Project period:** 2017-09-05 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980443

## Citation

> US National Institutes of Health, RePORTER application 9980443, Rational Integration of clinical SEquencing (RISE) (5R01HG009694-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9980443. Licensed CC0.

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