# Small and large animal surgery, physiology and histology

> **NIH NIH P01** · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $533,627

## Abstract

PROJECT SUMMARY
The Cardiac Physiology and Surgical Core (Core C) will be a focal point of the program by providing the
infrastructure to support numerous experimental approaches to assess cardiac physiology and pathology, in
the intact animal. Utilizing the vast experience and expertise of the Co-Director's, and well developed and
proven protocols for the assessment of cardioprotection in multiple animal models, the Core will not only
provide a consistent and reproducible service in support of the projects but will further participate in
experimental design, prioritization of resources, and the interpretation of data. In addition, Core C will identify
additional areas for collaboration across all projects as the program matures and thus be central to the
interactive environment and comprehensive analysis of the overall platform as data is generated. The
scientific core will provide a wide-range of services pertinent to the overall success of the program including
in both mouse and porcine models: delivery of novel cell-free exosome therapeutics to the myocardium, in
vivo induction of ischemia/reperfusion (IR) injury, the assessment of cardiac structure and function by multiple
methodologies, and histological and biochemical assessment of myocardial injury. These services will provide
the backbone for the major focus of this Program Project Grant to determine the impact of exosome therapy
on the molecular pathogenesis of cardiac IR-injury.

## Key facts

- **NIH application ID:** 9980466
- **Project number:** 5P01HL134608-04
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** John William Elrod
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $533,627
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980466

## Citation

> US National Institutes of Health, RePORTER application 9980466, Small and large animal surgery, physiology and histology (5P01HL134608-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9980466. Licensed CC0.

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