# Cortical bone stem cell-derived exosomes augment cardiac repair

> **NIH NIH P01** · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $454,465

## Abstract

Project Summary:
Adoptive transfer of multiple stem cell types into failing human hearts has demonstrated safety
however the beneficial effects in patients with cardiovascular disorders have been modest. Despite
increasing use of stem cell based therapies, there is no consensus on the optimal stem cell type.
Modest repair and improvement in patients with cardiac complications warrants identification of a
novel stem cell population that possesses youthful phenotype and effectively repair the heart after
myocardial environment. Recently we have shown in a mouse model that cortical bone derived stem
cells (CBSCs) enhance cardiac function after myocardial infarction and these beneficial effects
appear largely to be mediated by paracrine mechanisms. The fundamental basis of the project is to
investigate whether observed cardioprotection is mediated by secretion of exosomes from CBSCs.
Our preliminary data indicates that CBSCs derived exosomes recapitulate our earlier findings with
CBSCs transplantation and demonstrate effective way for cardiac repair. The hypothesis of this
research is to study the molecular contents (microRNA and paracrine factors) present in exosomes
derived from cortical bone stem cells. Additionally, we will test various exosome delivery approaches
together with the determination of optimal exosome dose in a large clinically relevant animal model.
Our proposed study will provide information on CBSCs unique protective signature molecules carried
by exosomes and swine animal model for heart repair that should provide basis for developing novel
therapies for treating heart failure patients.

## Key facts

- **NIH application ID:** 9980471
- **Project number:** 5P01HL134608-04
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Steven R Houser
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $454,465
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980471

## Citation

> US National Institutes of Health, RePORTER application 9980471, Cortical bone stem cell-derived exosomes augment cardiac repair (5P01HL134608-04). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9980471. Licensed CC0.

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