# Improving patient- and family-centered outcomes and value of care for patients with chronic illness who develop acute respiratory failure

> **NIH NIH K23** · UNIVERSITY OF WASHINGTON · 2020 · $190,188

## Abstract

PROJECT SUMMARY/ABSTRACT
Candidate: This K23 award will provide an opportunity for Dr. Khandelwal to achieve her long-term goal of
being an independently funded physician scientist with a focus on improving patient- and family-centered
outcomes for patients with acute respiratory failure (ARF) and their family members. Through this proposal,
Dr. Khandelwal will achieve her immediate goals of acquiring: 1) expertise in the evaluation of patient-and
family-reported outcomes, use of qualitative methods to inform the development and assessment of
interventions, and training in advanced multi-level statistical methods and clinical trials; and 2) pilot data and
skills to successfully apply for R level grants that include clinical trials and longitudinal cohort studies. These
objectives will be achieved through a career development plan that incorporates formal coursework, skilled
mentoring, and protected time to gain research experience in an outstanding environment.
Research: In this patient-oriented research proposal, Dr. Khandelwal will identify patients with ARF and
chronic illness who are at greatest risk for poor outcomes (psychological distress, functional impairment,
financial stress), and the types of supportive and palliative interventions that would be most helpful in
improving these outcomes. To accomplish this, she will: 1) identify predictors of poor patient and family
outcomes, including number and type of chronic conditions, measures of frailty, and prior healthcare use; 2)
identify predictors of high hospital and ICU utilization and costs; and 3) explore patient, family, and clinician
perspectives on the types, timing, and feasibility of supportive and palliative interventions that they believe
would improve these outcomes. To date, attempts to improve patient or family outcomes have been
disappointing and suggest the need for interventions targeted to specific populations and specific needs.
Findings from these aims will result in innovative interventions for patients with ARF who are at greatest risk for
poor outcomes and potentially burdensome, costly care. By efficiently targeting supportive and palliative care
resources to those who need and may benefit most, this study has the potential to improve value-driven care to
this vulnerable population.
Environment: The University of Washington (UW) is an ideal setting for Dr. Khandelwal's research training.
UW is an outstanding biomedical research institution with a strong commitment to promoting the academic
careers of promising investigators. The UW Department of Anesthesiology & Pain Medicine is widely
recognized for its support of early career physician scientists in development of the skills necessary to achieve
academic success. In addition to the resources provided within her Department, Dr. Khandelwal will also have
the full support of the Cambia Palliative Care Center of Excellence at UW (directed by her primary mentor) and
will have access to clinical research and biostatistic...

## Key facts

- **NIH application ID:** 9980486
- **Project number:** 5K23HL144830-02
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Nita Khandelwal
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $190,188
- **Award type:** 5
- **Project period:** 2019-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980486

## Citation

> US National Institutes of Health, RePORTER application 9980486, Improving patient- and family-centered outcomes and value of care for patients with chronic illness who develop acute respiratory failure (5K23HL144830-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980486. Licensed CC0.

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