# Core A: Lipidomics

> **NIH NIH P01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $258,055

## Abstract

SUMMARY 
The purpose of the Lipidomics Core in the PPG is to provide intellectual and physical resources (particularly 
state-of-the-art mass spectrometry analysis of sphingolipids and synthetic molecular tools) to enhance 
understanding of the role of bioactive lipids in cancer biology with the goal to discover future therapeutics. The 
diversity of bioactive lipids and their interconnected metabolism generates a network of pathways regulating 
intra- and inter-cellular signaling and function. Dysfunctions in these pathways contribute to the pathobiology of 
cancer progression and metastasis. These considerations have necessitated the development of lipid 
chemistry and analysis. The Lipidomics Core was created based on unique expertise of the key personnel in 
lipid chemistry, analysis, and metabolism. This Core has developed into an institutional, national, and 
international resource in the emerging fields of lipidomics and lipid chemical biology. Core services include: 1) 
Providing qualitative and quantitative analysis of lipid components from different biological materials (cells, 
tissue, and biological fluids), primarily employing high performance liquid chromatography-tandem mass 
spectrometry (HPLC-MS/MS) technology—the Core currently provides quantitative analysis of more than 300 
distinct lipid molecular species at a basic metabolomic level; 2) Developing and providing synthetic molecular 
tools to study lipid metabolism (e.g., functionalized and fluorescent ceramides, site-specific radioactive 
sphingolipids, 17C-sphingolipids) and diversified synthetic lipids and analogs for cellular, in vitro, and in vivo 
studies (e.g., organelle-targeted sphingolipids and organelle-targeted inhibitors of sphingolipid metabolizing 
enzymes); 3) Providing direct MALDI-MS tissue analysis to visualize the distribution of lipid based anti-cancer 
drugs and their molecular effects on sphingolipid components; and 4) Assisting PPG investigators in 
experimental design, selection of lipids of interest, and interpretation of analytical results.

## Key facts

- **NIH application ID:** 9980700
- **Project number:** 5P01CA203628-05
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** ALICJA BIELAWSKA
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $258,055
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980700

## Citation

> US National Institutes of Health, RePORTER application 9980700, Core A: Lipidomics (5P01CA203628-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980700. Licensed CC0.

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