# Core C:  Clinical Resarch Laboratory

> **NIH NIH P01** · UNIVERSITY OF RHODE ISLAND · 2020 · $752,492

## Abstract

Project Summary/Abstract
 This Program Project takes a comprehensive approach to investigating dengue virus (DENV)
transmission within a family setting (Project 1), defining the early immune response to DENV and its correlations
to outcomes (Project 2), and investigating immune responses in DENV vaccine recipients (Project 3). These
projects include studies with distinct experimental designs with two large prospective cohorts conducted in two
countries (Thailand and the Philippines). This complex and integrative research effort will be supported by a
laboratory core (Core C) which will provide high quality laboratory support for specimen processing, management,
and routine clinical and dengue diagnostic laboratory testing. The Clinical Research Laboratory Core (Core C)
consists of 3 facilities: a) AFRIMS-Virology laboratory in Bangkok, Thailand (Core C-BKK), b) AFRIMS-Virology
laboratory in Kamphaeng Phet (Core C-KPP), Thailand, and c) AFRIMS-Virology laboratory in Cebu, the
Philippines (Core C-Cebu). Core C-BKK has been conducting research in Southeast Asia and nearby regions
for over 50 years and has served as a reference laboratory for flavivirus diagnosis; it will serve as the
administrative and logistics center for laboratory activities and will be the main laboratory for serologic diagnosis
and for study-specific specialized tests. Core C-KPP will be the main facility for specimen processing for Projects
1 and 2; it will also serve as a molecular diagnostic laboratory and perform research laboratory testing including
assessment of viral burden and analysis of immune responses by flow cytometry and antigen and antibody
assays. Core C-Cebu is currently the main specimen processing facility for samples collected from dengue
vaccine study subjects in Project 3. The Core Laboratory will be the center for specimen storage, inventory, and
distribution. The Core Laboratory has a secure and accountable inventory system that has facilitated sample
distribution to diagnostic and research laboratories. Since the beginning of the Program Project, the Core
Laboratory has processed and managed specimens including plasma/serum, cryopreserved PBMC, and RNA
from PBMC. These samples have been used for functional antibody assays, assays for biological mediators,
and molecular and proteomic analyses that have been published and contributed to current understanding on
many aspects of dengue. Study-specific quality management plans have been established and the laboratory’s
operation is audited quarterly for specimen chain custody, specimen handling, and sample accountability.

## Key facts

- **NIH application ID:** 9980772
- **Project number:** 5P01AI034533-28
- **Recipient organization:** UNIVERSITY OF RHODE ISLAND
- **Principal Investigator:** Anon Srikiatkhachorn
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $752,492
- **Award type:** 5
- **Project period:** 1997-01-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980772

## Citation

> US National Institutes of Health, RePORTER application 9980772, Core C:  Clinical Resarch Laboratory (5P01AI034533-28). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9980772. Licensed CC0.

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