# Project 1:  Kamphaeng Phet Family Cohort Study

> **NIH NIH P01** · UNIVERSITY OF RHODE ISLAND · 2020 · $328,444

## Abstract

Project Abstract
This research proposal, entitled “Familial force of infection and dengue disease burden in
Thailand” involves studies in the United States and Thailand to understand how members within
a family of all ages respond to exposure to dengue virus and what their clinical outcome is if
infected. This is a unique study following 500 families and approximately 3,000 family members
in Northern Thailand over a total of 10 years to understand how people’s response to infection
changes over time and to different types of dengue virus. This study will allow us to understand
the immune response from multiple ages in one family; understand how people are protected
from infection or not; and determine the factors on how dengue is spread in the population.
This project is a unique opportunity to follow families across 10 years of intense exposure to
dengue transmission in an area hyperendemic for dengue. Project activities focus on defining
the familial burden of dengue infection, understanding the role of herd immunity in transmission
dynamics, and identifying correlates of protection and correlates of disease severity. These
activities are derived from our central objectives of understanding dengue pathogenesis and
identifying risk factors for infection and transmission. This project and its objectives are highly
relevant to the overall objectives of the Program Project which are to advance methods to
prevent and treat dengue-related infection and illness.

## Key facts

- **NIH application ID:** 9980773
- **Project number:** 5P01AI034533-28
- **Recipient organization:** UNIVERSITY OF RHODE ISLAND
- **Principal Investigator:** Timothy Paul Endy
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $328,444
- **Award type:** 5
- **Project period:** 1997-01-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980773

## Citation

> US National Institutes of Health, RePORTER application 9980773, Project 1:  Kamphaeng Phet Family Cohort Study (5P01AI034533-28). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9980773. Licensed CC0.

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