# CELL IMAGING CORE

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $113,107

## Abstract

PROJECT SUMMARY - VDDRC CELL IMAGING CORE
We are fortunate at Vanderbilt to have one of the leading facilities for microscopic imaging of digestive
disease-related processes. Thus, the Vanderbilt Digestive Disease Research Center (VDDRC) will continue
to support the VDDRC Cell Imaging Core, operated by the Cell Imaging Shared Resource (CISR), and ensure
that VDDRC-affiliated investigators will have full access to state-of-the-art imaging equipment and expert
technical support to conduct sophisticated microscopy and analysis of tissue and cellular anatomy and
physiology. By utilizing a large, well-established facility, the VDDRC Cell Imaging Core provides high levels of
quality control, a dedicated, expert staff and a significant economy of scale for services that would be difficult (if
not impossible) for individual investigators to establish and support. This organizational structure fits well with
the centralized approach to prevent needless duplication of scientific resources within federally funded
research centers, enabling focused development of technology that serves all Vanderbilt research, including
VDDRC investigators. The overall goal of the VDDRC Cell Imaging Core is to provide the full range of modern
microscopy and digital imaging capabilities and techniques to enable and accelerate digestive disease
research at Vanderbilt through three objectives: 1) acquire and maintain state-of-the art optical and EM
imaging technology; 2) train, assist, and encourage VDDRC-affiliated investigators to incorporate optical,
EM, and in vivo imaging technologies into their research; and 3) develop new imaging technologies that will
be useful for digestive disease research. Without VDDRC support, the breadth and quality of advanced
microscopy service would be weakened, thus thinning resources available to advance digestive disease
research. The VDDRC support grant also reduces the net cost of imaging service to VDDRC investigators and
has helped provide financial stability essential to sustain historically high levels of service to VDDRC
researchers. This stability has been vital to the successful acquisition of new instruments and services that
support VDDRC researchers. During the past 5 years, investigators representing 71 separate VDDRC-
affiliated laboratories have used all aspects of the CISR. Over the same period, the CISR initiatives taken to
obtain equipment grants, combined with institutional contributions, have provided $4,766,063 in new capital
equipment, managed by the CISR, for the benefit of VDDRC investigators. This includes super-resolution, 2-
photon-excited fluorescence, multi-excitation TIRF, and other advanced microscopies. The Vanderbilt shared
facilities system provides an efficient billing system, oversight and governance for the Cell Imaging Core at no
extra cost to VDDRC members. The VDDRC Cell Imaging Core will continue to be a critical component in
Vanderbilt's broad range of digestive disease research resources and will pr...

## Key facts

- **NIH application ID:** 9980892
- **Project number:** 5P30DK058404-19
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** MATTHEW J TYSKA
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $113,107
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980892

## Citation

> US National Institutes of Health, RePORTER application 9980892, CELL IMAGING CORE (5P30DK058404-19). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980892. Licensed CC0.

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