# MASS SPECTROMETRY/PROTEOMICS CORE

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $138,747

## Abstract

PROJECT SUMMARY – VDDRC MASS SPECTROMETRY (MS) AND PROTEOMICS CORE
The MS/Proteomics Core provides cost-effective, state-of-the-art instrumentation and expertise to investigators
in the Vanderbilt Digestive Disease Research Center (VDDRC). This core leverages the expert personnel and
cutting edge instrument facilities located in the Vanderbilt Mass Spectrometry Research Center (MSRC) to
provide specialized services to VDDRC members. This core will be used for identification and quantitation of
small molecule metabolites and elements, identification and characterization of proteins, and biomolecular
imaging/profiling in tissues. Forty-one (41) VDDRC investigators have used the core extensively during the
previous five years for digestive disease related projects. Services used include: analytical method
development, assistance with experimental design, quantification of protein expression differences with isotope
tagging methods, phosphoproteome characterization, identification of post-translational modifications,
elemental analysis by ICP-MS, and bioinformatics analysis. The core develops standard operating procedures,
maintains quality control (QC) records on particular assays and instrument performance, and records
maintenance history. Core personnel perform assays for investigators and train students and fellows in the
theoretical and practical aspects of MS. The small molecule/metabolite component of the core is run as an
open-access facility in which users can choose to prepare their samples and operate the instruments.
Proteomics samples are submitted to the core for analysis by proteomics staff after consultations between the
investigator and core staff on the most appropriate experimental design, sample preparation and instrumental
analysis methods. Administrative staff monitors the use of the instrument facilities by investigators and prepare
reports on utilization for use by the Administrative Core. The core has 25 mass spectrometers available to
users, in addition to specialized instrumentation for advanced analyses. The Specific Aims of the Core are to:
1) provide high-quality GC/MS, tandem LC/MS, and MALDI/TOF mass spectrometry services for analysis of
small molecule metabolites; 2) provide proteomics services for identification and quantification of proteins; 3)
provide imaging mass spectrometry services for proteins, lipids and metabolites in tissues; 4) provide analytical
expertise in mass spectrometry for assay development and validation; 5) assist users with data analysis; and
6) provide advanced training in bioinformatics of proteomics data; and 7) promote interactions between
VDDRC Cores. The overarching goal of the Core is to enhance VDDRC investigator abilities to prevent,
diagnose or treat human digestive disease-related disorders.

## Key facts

- **NIH application ID:** 9980898
- **Project number:** 5P30DK058404-19
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** RICHARD M CAPRIOLI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $138,747
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9980898

## Citation

> US National Institutes of Health, RePORTER application 9980898, MASS SPECTROMETRY/PROTEOMICS CORE (5P30DK058404-19). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9980898. Licensed CC0.

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