# The Jackson Laboratory Gene Editing Testing Center (JAX-GETC)

> **NIH NIH U42** · JACKSON LABORATORY · 2020 · $764,285

## Abstract

PROJECT SUMMARY OVERALL SECTION
The JAX Genome Editing Mouse Testing Center (JAX-GEMTC) aims to capitalize on the convergence of rapid
advances in genome editing technology and the maturity of gene therapy platforms to achieve fundamental
breakthroughs in the treatment of genetic disease. To accomplish this mission, the JAX-GEMTC will build novel
reporter mouse line platforms for robust and sensitive detection of editing activity, and use these models to
support the in vivo evaluation of new delivery technologies and editors. This Center draws upon the unique
expertise and unparalleled mouse genetic resources at JAX, fortified by an 80-year history of mouse biology
research. We have assembled a talented, multi-functional team organized into discrete components that
leverage JAX institutional pipelines and resources. The three research components—the Animal Model
Production Unit, the Gene Editing Testing Core, and the Animal Model Resource Core—are tightly coordinated
by the Center leadership, and build primarily upon existing research and management teams. The Center
supplements these pipelines with collaborations that add unique resources and skills to accelerate our
implementation and expand the potential scope of our impact. The overall Aims of the JAX-GEMTC are: 1) To
develop a mouse model resource, including a panel of reporter models, to robustly monitor genome editing
activity and cell-type specificity in vivo. 2) To establish a multi-disciplinary team of experts and to develop a
scalable platform to support the delivery of genome editing components and analysis of editing outcomes. 3) To
engage with and contribute to the Somatic Cell Genome Editing (SCGE) consortium by deploying systems to
share both data and animal resources. 4) To develop a framework for future collaborative expansion of our
program, taking advantage of our expertise and the scalability of our mouse model generation and in vivo
manipulation platforms. The successful completion of these aims will fuel the goals of the SCGE program, which
aims to improve genome editing technologies to accelerate the translation of this technology into clinical
applications and maximize the potential to treat as many diseases as possible.

## Key facts

- **NIH application ID:** 9981492
- **Project number:** 5U42OD026635-03
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** Cathleen M Lutz
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $764,285
- **Award type:** 5
- **Project period:** 2018-09-18 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981492

## Citation

> US National Institutes of Health, RePORTER application 9981492, The Jackson Laboratory Gene Editing Testing Center (JAX-GETC) (5U42OD026635-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9981492. Licensed CC0.

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