# Core D: Neuropathology Core

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $346,250

## Abstract

Neuropathology Core (Core D) – Project Summary
 The Neuropathology Core will provide state-of-the-art collection, storage, and distribution of brain and other
biospecimens, establish neuropathological diagnoses of decedent Clinical Core participants, and provide
resources and expertise for nonhuman primate (NHP) models for pivotal mechanistic and therapeutic AD
research. The Core will oversee repositories derived from longitudinal collection of biospecimens obtained from
adults at high risk for AD due to genetic and metabolic risk factors, as well as low-risk adults, and adults with
MCI and AD, and from analogous studies in NHPs. These repositories will provide unique opportunities to
identify novel biomarkers, neurodegenerative antecedents, and therapeutic targets, and will be made available
to NCRAD and to ADC investigators. The Core utilizes an innovative inter-institutional leadership model in
which a team of neuropathologists from Wake Forest and the University of Washington will employ state-of-
the-art virtual microscopy, webconferencing, and biospecimen sharing to accelerate the development of
Neuropathology operations at the newly established Wake Forest ADCC. Interinstitutional publication has
already resulted, and an NHP study of age-associated AD-like neuropathology completed which provide proof
of concept for this approach. Thus, we will accomplish the following Specific Aims: 1) To oversee a repository
of brain tissue, CSF, DNA, and blood from participants enrolled in the Clinical and MESA Cores of the Wake
Forest ADCC, using state-of-the-art methods for specimen collection, processing, storage, and distribution; 2)
To facilitate distribution of data and specimens in the repository to Wake ADCC and ADC network
investigators, as well as to NCRAD and AD researchers world-wide; 3) To conduct rigorous neuropathological
diagnostic evaluations and clinical-pathological investigations of decedent Clinical and MESA Core
participants, using an innovative inter-institutional model that incorporates the latest technology in virtual
microscopy and web conferencing; 4) To facilitate the measurement of key biomarkers of AD pathology and
innovative markers of metabolic/vascular function; and 5): To establish preclinical models of AD and
pathological brain aging in NHPs using procedures analogous to human protocols, and in doing so (a) create a
repository of brain tissue, CSF, DNA, biospecimens, and neuroimaging data, and (b) NHP cohorts and rodent
models, that can be used for pivotal mechanistic and therapeutic studies.

## Key facts

- **NIH application ID:** 9981586
- **Project number:** 5P30AG049638-05
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Thomas J Montine
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $346,250
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981586

## Citation

> US National Institutes of Health, RePORTER application 9981586, Core D: Neuropathology Core (5P30AG049638-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9981586. Licensed CC0.

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