# Structural Biology (SB)

> **NIH NIH P30** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2020 · $114,447

## Abstract

Project Summary/Abstract: Structural Biology Facility 
The overall goal of the Structural Biology (SB) Facility is to apply three-dimensional structural visualization 
techniques to the analysis of important cancer-related biological macromolecules. Such structural data can 
provide basic knowledge of disease mechanism and drive research. Atomic visualization of active sites and 
protein-protein interactions can direct the synthesis of novel therapeutics. The co-directors and staff of the SB 
Facility make access to these sophisticated, highly-technical biophysical methods easy for members of the 
cancer center. The SB Facility was initiated ten years ago, through funding from the Nebraska Research 
Initiative (NRI) and the Vice Chancellor for Research. The SB Facility has five complimentary laboratory 
components: Protein expression and purification (PrEP), crystal screening and growth (CSG), X-ray 
crystallography data collection, small-angle X-ray scattering (SAXS) data collection and nuclear magnetic 
resonance (NMR) data collection. The PrEP component is a central part of the facility and prepares samples 
for CSG (and subsequently X-ray crystallography), SAXS and/or NMR. The SB Facility is run with a solid 
“collaborative” business plan that includes fees collected upon production of samples and/or use of the 
instrumentation, as well as, inclusion of costs in collaborative grant proposals. Data provided from the SB 
Facility has helped fund numerous external grant proposals including those from NIH, NSF and NASA. 
Numerous collaborative, peer-reviewed publications in cancer research as well as invited review articles have 
resulted from the SB Facility.

## Key facts

- **NIH application ID:** 9981653
- **Project number:** 5P30CA036727-34
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** Gloria Borgstahl
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $114,447
- **Award type:** 5
- **Project period:** 1997-09-05 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981653

## Citation

> US National Institutes of Health, RePORTER application 9981653, Structural Biology (SB) (5P30CA036727-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9981653. Licensed CC0.

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