# Cancer Genes and Molecular Regulation (CGMR)

> **NIH NIH P30** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2020 · $59,992

## Abstract

Project Summary/Abstract: Cancer Genes and Molecular Regulation Program (CGMRP) 
The overall goal of the Cancer Genes and Molecular Regulation Program (CGMRP) is to develop strategies for 
the identification and validation of cellular targets for cancer therapy, and for the discovery of small molecules 
and delivery methods that affect target function. The CGMRP has 28 members from nine departments with 
multidisciplinary interests in cancer target discovery and development. Nine new members have been recruited 
to the CGMRP over the previous period of funding. The program membership has technical strengths in super- 
resolution microscopy, high throughput RNA interference, small molecule screening and delivery, synthetic and 
medicinal chemistry, and the development of evaluative preclinical models. The research interests of the 
program faculty are organized around three themes: cancer target identification, cancer target validation, and 
drug delivery/translational development. Investigators within the cancer target identification theme are focused 
on developing conceptually and technically novel approaches that can be used for the discovery of cancer 
targets. Investigators within the cancer target validation theme analyze putative targets for cancer therapy and 
develop and evaluate small molecules directed at those targets. Investigators focused on drug delivery and 
translational research within the CGMRP analyze and test novel models for cancer therapy and methods for 
drug delivery. The Co-Directors leverage their expertise to enhance inter- and intra-programmatic collaboration 
through the development of new shared resources, the evaluation and funding of pilot projects supporting the 
CGMRP mission, the attraction of high profile speakers for Cancer Center Grand Rounds and regular seminar 
series, and the organization of monthly programmatic meetings. These activities have promoted a strongly 
collaborative group as demonstrated by inter- and intra-programmatic publications and grants, and the 
generation of new clinical trials based on discoveries from CGMRP investigators. 637 cancer-related 
manuscripts were published by CGMRP investigators during the previous funding period, of which 25% were 
intra-programmatic, 20% were inter-programmatic publications, and 6% are both intra- and inter-programmatic. 
The CGMRP has $6.66M in total peer-reviewed funding ($4.67M direct) of which 50% is from the National 
Cancer Institute.

## Key facts

- **NIH application ID:** 9981657
- **Project number:** 5P30CA036727-34
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** Robert E. Lewis
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $59,992
- **Award type:** 5
- **Project period:** 1997-09-05 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981657

## Citation

> US National Institutes of Health, RePORTER application 9981657, Cancer Genes and Molecular Regulation (CGMR) (5P30CA036727-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9981657. Licensed CC0.

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