# Mid-Career Award in Patient-Oriented Substance Use Research Addressing Opioids, Chronic Pain, and HIV

> **NIH NIH K24** · SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH · 2020 · $151,319

## Abstract

Project Abstract
This K24 award will support the candidate’s development as a mentor and substance use researcher, while
completing a study the impact of reduced or discontinued opioid therapy on patients infected with HIV. The
candidate will complete advanced training in mentoring and meet regularly with senior mentors to improve his
mentoring, while increasing his mentoring load throughout the award period. He will also enhance his ability to
excel as a substance use researcher addressing opioid use and chronic pain by completing American Board of
Addiction Medicine board certification and the American Pain Society Fundamentals of Pain Medicine course,
completing independent structured reading programs addressing pain research as well as biostatistics and
research design, and gaining direct clinical experience in chronic pain management. In addition, the candidate
will pursue new research to examine the impact of discontinuation of prescription opioid use among HIV-
positive patients. The candidate will perform extensive chart extraction research on 600 patients prescribed
opioids for chronic pain (300 HIV-positive, 300 frequency-matched HIV-negative) in years 1-2 and 3-4 of the
award period in order to characterize the trajectory of opioid prescribing and rationale for continuation or
changes in opioid therapy, compare opioid prescribing patterns and yellow flag behaviors among HIV-positive
and HIV-negative patients, and prospectively assess the relationship between receipt of prescription opioids
and clinic care of HIV-positive and HIV-negative patients. Analysis will involve pooled logistic regression
modeling adjusted for frequency-matching strata, and generalized estimating equations, depending on the
hypothesis being tested.

## Key facts

- **NIH application ID:** 9981708
- **Project number:** 5K24DA042720-05
- **Recipient organization:** SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
- **Principal Investigator:** PHILLIP O COFFIN
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $151,319
- **Award type:** 5
- **Project period:** 2016-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981708

## Citation

> US National Institutes of Health, RePORTER application 9981708, Mid-Career Award in Patient-Oriented Substance Use Research Addressing Opioids, Chronic Pain, and HIV (5K24DA042720-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9981708. Licensed CC0.

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