# Effect of Genotype on Resting State Connectivity During Methamphetamine Administration

> **NIH NIH R21** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $189,000

## Abstract

Project Summary
Methamphetamine dependence is a widespread problem that crosses socioeconomic boundaries and causes
substantial medical morbidity and economic burden. This project uses genetics and neuroimaging techniques
to investigate the neurobiology of addiction to methamphetamine as it relates to the TAAR1 trace amine
receptor. We hypothesize that individuals with a common TAAR1 genetic variant (v288v) will have a blunted
response to methamphetamine on tests of attention and cognitive control as well as on striato-limbic resting
state functional connectivity (RSFC).
SA 1. Determine the influence of htaar1 common variant (CV) vs. wild type (WT) genotype on RSFC and
craving in chronic MUD.
SA 2: Determine the effect of acute oral MA or placebo (PBO) administration on the interaction of htaar1 CV
vs. WT genotype on RSFC, craving, cognitive control, attention and subjective experience in MUD.
This project will consent and enroll up to 100 subjects who will be screened for TAAR1 genotype and placed
into one of two groups: one which will include subjects who are wild type (WT) for the TAAR1 gene and those
who are either homozygous or heterozygous for the CV, v288v. Others will be screened out of the study. A
partner lab will determine genotype so that study staff and subjects will be blinded to genotype. Subjects will
be administered methamphetamine and placebo in a blinded, randomized manner over two visits and
evaluated with resting state fMRI, subjective effects and behavioral tasks. RSFC comparisons of meth versus
placebo and comparisons of WT versus CV groups will be evaluated.

## Key facts

- **NIH application ID:** 9981723
- **Project number:** 5R21DA047602-02
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** William Franklin Hoffman
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $189,000
- **Award type:** 5
- **Project period:** 2019-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981723

## Citation

> US National Institutes of Health, RePORTER application 9981723, Effect of Genotype on Resting State Connectivity During Methamphetamine Administration (5R21DA047602-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9981723. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*