# CenteringPregnancy Oral Health Promotion (CPOP) Clinical Trial

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $1,294,962

## Abstract

Abstract
Federal agencies and professional organizations have mounted a large effort to address an increasingly
recognized public health problem – poor perinatal oral health – which has serious implications for maternal and
child health and is largely preventable. Several national organizations have issued statements prioritizing the
need to improve oral health and access to oral health care during pregnancy and the National Maternal and
Child Health Bureau has released consensus statements and clinical guidelines on perinatal oral health care
during pregnancy. The provision of the recommended oral health care during pregnancy has the potential to
improve women's oral health through improved prevention and restorative care and to promote children's oral
health through caregiver education and timely anticipatory guidance.
Through funding from the NIDCR (R21DE019211 Adams, PI; U54 DE019285 Chung, PI), we developed and
pilot tested the CenteringPregnancy Oral Health Promotion (“CPOP”) Intervention, an oral health intervention
for pregnant women attending CenteringPregnancy® (CP), a group prenatal care program. The CPOP
intervention consists of 2 educational and skills building modules (maternal and infant) that are integrated into
the CP curriculum, and delivered by trained CP facilitators. To evaluate the modules, the women completed
dental examinations and questionnaires assessments of OH knowledge, attitudes, and behaviors at pre- and
post- intervention periods. Infant and maternal salivary bacterial levels were assessed when the infants were 6
and 12 months of age. Findings from the CPOP pilot studies show significant improvements in maternal and
infant clinically-assessed oral health. NIDCR funding (R34DE024574) has supported the development of the
final planning and preparation for the U01 CPOP RCT.
The purpose of this U01 proposal is to test the efficacy of the CPOP intervention as a full scale Phase III
randomized controlled trial among a group of women receiving CP prenatal care at sites across Northern
California. If shown to be efficacious, CPOP could be implemented rapidly and broadly nationwide.

## Key facts

- **NIH application ID:** 9981724
- **Project number:** 5U01DE027340-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** SALLY Henderson ADAMS
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,294,962
- **Award type:** 5
- **Project period:** 2018-08-13 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9981724

## Citation

> US National Institutes of Health, RePORTER application 9981724, CenteringPregnancy Oral Health Promotion (CPOP) Clinical Trial (5U01DE027340-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9981724. Licensed CC0.

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