# Pittsburgh Pelvic Floor Research Program

> **NIH NIH UG1** · MAGEE-WOMEN'S RES INST AND FOUNDATION · 2020 · $245,229

## Abstract

PROJECT SUMMARY
The purpose of this proposal is to demonstrate the capabilities of the University of Pittsburgh to participate as a
clinical site in the NICHD-sponsored Pelvic Floor Disorders Network (PFDN). Our site has a longstanding
track record of successful contribution to multicenter studies of urinary and fecal incontinence, and pelvic organ
prolapse. We are particularly well suited to be a clinical site in the PFDN because of our volume, research
infrastructure and track record, basic and translational experience and expertise. Access to large numbers of
nulliparous women enables us to contribute uniquely to studies of the role of pregnancy and parturition in the
etiology and prevention of pelvic floor disorders (PFDs). Magee-Womens Hospital (MWH) is the central
resource for gynecologic specialty care for the 19 hospital University of Pittsburgh Health System serving a
very large aging population. Our site brings expertise in urogynecology, physical therapy, urology,
gastroenterology, geriatrics, and biomechanical engineering. We offer unique technical expertise in
development of finite element models of the vagina and its supportive tissues after surgery, biochemical and
biomechanical impact of meshes on the vagina, dynamic 3D MRI and transperineal ultrasound of the pelvic
floor, tissue regenerative techniques, genomics, proteomics, and central neuronal control of bladder function.
In this application we describe: 1. our experience and productivity in multicenter randomized trials and clinical
trials networks, our available population for enrollment and the clinical expertise of investigators; 2. special
strengths of our transdisciplinary translational investigators; 3. our research personnel staffing and
management plan for recruitment and retention of subjects in PFDN trials.

## Key facts

- **NIH application ID:** 9982079
- **Project number:** 5UG1HD069006-10
- **Recipient organization:** MAGEE-WOMEN'S RES INST AND FOUNDATION
- **Principal Investigator:** HALINA M ZYCZYNSKI
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $245,229
- **Award type:** 5
- **Project period:** 2011-08-01 → 2022-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9982079

## Citation

> US National Institutes of Health, RePORTER application 9982079, Pittsburgh Pelvic Floor Research Program (5UG1HD069006-10). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9982079. Licensed CC0.

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