# Biostatistics and Bioinformatics

> **NIH NIH P01** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $285,322

## Abstract

ABSTRACT
The overarching goal of the program project, “Systems Biology of Airway Disease”, is to identify common
molecular determinants and pathways for asthma and COPD. These determinants will be identified through the
use of a diverse array of molecular data — DNA sequencing and genomewide SNP data (Project 1), RNA
sequencing and expression data (Project 2), methylation sequencing and miRNA sequencing data (Project 3).
In order to meet the goals of this project, extensive biostatistical and bioinformatics support is necessary and
will be implemented throughout each of the three projects. As such, we have established a Biostatistics and
Bioinformatics Core (Core B) that will meet these needs for the program project. Specifically, we will
develop/refine bioinformatics pipelines for DNA, RNA and methylation sequencing data to ensure that the
sequencing data to be generated will be of high quality and are managed properly. These pipelines will be
incorporated into the existing bioinformatics structure that supports the other molecular data being used
throughout this PPG. Several of the goals throughout the three projects are innovative in nature and are best
addressed through the development of new statistical methods that are specific to the project aims. As such,
this core will also develop and distribute novel statistical genetics methods and software necessary to meet the
specific needs of each of the projects. Finally, the goals for each project require extensive statistical analyses.
This core will oversee the statistical analyses throughout the PPG, ensuring that the analyses are appropriate
and completed in a timely manner. The Biostatistics and Bioinformatics Core will be directed by Dr. Christoph
Lange, Professor of Biostatistics at the Harvard School of Public Health (HSPH), with a joint appointment as
Assistant Professor of Medicine at the Harvard Medical School (HMS). In addition, there is a team of
experienced statisticians, bioinformaticists and bioinformaticians who are longtime collaborators with each
other and with the Project Leaders, Dr. Scott T. Weiss (Project 1), Dr. Benjamin A. Raby (Project 2) and Dr.
Dawn L. DeMeo (Project 3). Their successful track record and productivity suggests that the Biostatistics and
Bioinformatics team will work successfully to help meet the overall needs of this PPG.

## Key facts

- **NIH application ID:** 9982411
- **Project number:** 5P01HL132825-05
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** CHRISTOPH LANGE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $285,322
- **Award type:** 5
- **Project period:** 2016-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9982411

## Citation

> US National Institutes of Health, RePORTER application 9982411, Biostatistics and Bioinformatics (5P01HL132825-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9982411. Licensed CC0.

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