# A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer

> **NIH NIH R50** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $257,484

## Abstract

Project Summary/ Abstract
The Paulovich laboratory is a translational oncology lab specializing in proteomics with a goal to improve
personalized medicine through elucidating cancer mechanisms, diagnosing disease, and predicting response
to therapy. A major roadblock to achieving these goals is the lack of standardized assays for the quantification
of proteins, which form the basis of diagnostics and are targets for treatments. To address this need, our
research program is focusing on three arms: i) the development of novel applications of targeted mass
spectrometry for precise, multiplexed, and reproducible quantitation of proteins, ii) the standardization of
protein measurements through establishing community resources for the dissemination of the technology to
the biomedical research community, and iii) the measurement of proteins and post-translational modifications
in biological samples for fundamental biological insight to cancer mechanisms and translating findings to
clinical use. Dr. Jeffrey Whiteaker, a research specialist in the Paulovich laboratory, is vital to achieving
success in this interdisciplinary effort due to: his role as leader of all proteomics activities in the laboratory, his
vast experience in the field of analytical chemistry and mass spectrometry, and the guidance he provides
within the laboratory. He will continue to guide efforts aimed at expanding the technology to cancer-relevant
pathways and disseminating the technology to the biomedical research community, enabling the translation of
new discoveries to clinical care and the benefit of patients.

## Key facts

- **NIH application ID:** 9982969
- **Project number:** 5R50CA211499-05
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** Jeff Whiteaker
- **Activity code:** R50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $257,484
- **Award type:** 5
- **Project period:** 2016-09-19 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9982969

## Citation

> US National Institutes of Health, RePORTER application 9982969, A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer (5R50CA211499-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9982969. Licensed CC0.

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